<?xml version="1.0" encoding="UTF-8"?>
<oai_dc:dc xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:title>Minimization Tool for Pharmacokinetic-Pharmacodynamic Data
Analysis</dc:title>
  <dc:title>R package wnl version 0.8.6</dc:title>
  <dc:subject>CRAN Task View: Pharmacokinetics (https://CRAN.R-project.org/view=Pharmacokinetics)</dc:subject>
  <dc:description>This is a set of minimization tools (maximum likelihood estimation and least square fitting) to solve examples in the Johan Gabrielsson and Dan Weiner's book "Pharmacokinetic and Pharmacodynamic Data Analysis - Concepts and Applications" 5th ed. (ISBN:9198299107). Examples include linear and nonlinear compartmental model, turn-over model, single or multiple dosing bolus/infusion/oral models, allometry, toxicokinetics, reversible metabolism, in-vitro/in-vivo extrapolation, enterohepatic circulation, metabolite modeling, Emax model, inhibitory model, tolerance model, oscillating response model, enantiomer interaction model, effect compartment model, drug-drug interaction model, receptor occupancy model, and rebound phenomena model. </dc:description>
  <dc:type>Software</dc:type>
  <dc:relation>Depends: R (&gt;= 3.5.0)</dc:relation>
  <dc:relation>Imports: numDeriv</dc:relation>
  <dc:creator>Kyun-Seop Bae &lt;k@acr.kr&gt;</dc:creator>
  <dc:publisher>Comprehensive R Archive Network (CRAN)</dc:publisher>
  <dc:contributor>Kyun-Seop Bae [aut, cre, cph]</dc:contributor>
  <dc:rights>GPL-3</dc:rights>
  <dc:date>2026-07-26</dc:date>
  <dc:format>application/tgz</dc:format>
  <dc:identifier>https://CRAN.R-project.org/package=wnl</dc:identifier>
  <dc:identifier>doi:10.32614/CRAN.package.wnl</dc:identifier>
</oai_dc:dc>