Computing Weighted Topological Overlaps (wTO) & Consensus wTO Network R package wTO version 2.1 Computes the Weighted Topological Overlap with positive and negative signs (wTO) networks given a data frame containing the mRNA count/ expression/ abundance per sample, and a vector containing the interested nodes of interaction (a subset of the elements of the full data frame). It also computes the cut-off threshold or p-value based on the individuals bootstrap or the values reshuffle per individual. It also allows the construction of a consensus network, based on multiple wTO networks. The package includes a visualization tool for the networks. More about the methodology can be found at <doi:10.1186/s12859-018-2351-7>. Software Imports: data.table, igraph, magrittr, plyr, parallel, som, visNetwork, reshape2, Rfast, HiClimR, methods Suggests: knitr, rmarkdown Deisy Morselli Gysi <deisy.ccnr@gmail.com> Comprehensive R Archive Network (CRAN) Deisy Morselli Gysi, Andre Voigt, Tiago Miranda Fragoso, Eivind Almaas and Katja Nowick. GPL-2 2024-07-04 application/tgz https://CRAN.R-project.org/package=wTO doi:10.32614/CRAN.package.wTO