<?xml version="1.0" encoding="UTF-8"?>
<oai_dc:dc xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:title>Utilities and Design Aids for Up-and-Down Dose-Finding Studies</dc:title>
  <dc:title>R package upndown version 0.3.0</dc:title>
  <dc:description>Up-and-Down (UD) is the most popular design approach for dose-finding, but it has been severely under-served by the statistical and computing communities. This is the first package that comprehensively addresses UD's needs. Recent applied UD tutorial: Oron et al., 2022 &lt;doi:10.1097/ALN.0000000000004282&gt;. Recent methodological overview: Oron and Flournoy, 2024 &lt;doi:10.51387/24-NEJSDS74&gt;.</dc:description>
  <dc:type>Software</dc:type>
  <dc:relation>Imports: cir, expm, MASS, plyr</dc:relation>
  <dc:relation>Suggests: knitr, rmarkdown</dc:relation>
  <dc:creator>Assaf P. Oron &lt;assaf.oron@gmail.com&gt;</dc:creator>
  <dc:publisher>Comprehensive R Archive Network (CRAN)</dc:publisher>
  <dc:contributor>Assaf P. Oron [cre, aut]</dc:contributor>
  <dc:rights>GPL-2</dc:rights>
  <dc:date>2025-06-16</dc:date>
  <dc:format>application/tgz</dc:format>
  <dc:identifier>https://CRAN.R-project.org/package=upndown</dc:identifier>
  <dc:identifier>doi:10.32614/CRAN.package.upndown</dc:identifier>
</oai_dc:dc>