DE Analysis for Single-Cell RNA-Sequencing Data R package twosigma version 1.0.2 Implements the TWO-Component Single Cell Model-Based Association Method (TWO-SIGMA) for gene-level differential expression (DE) analysis and DE-based gene set testing of single-cell RNA-sequencing datasets. See Van Buren et al. (2020) <doi:10.1002/gepi.22361> and Van Buren et al. (2021) <doi:10.1101/2021.01.24.427979>. Software Imports: multcomp (>= 1.4-13), glmmTMB, methods, pscl (>= 1.5.5), pbapply (>= 1.4.0), parallel (>= 3.6.3), doParallel (>= 1.0.15) Suggests: testthat Eric Van Buren <edvanburen@gmail.com> Comprehensive R Archive Network (CRAN) Eric Van Buren [aut, cre], Yun Li [aut], Di Wu [aut], Ming Hu [aut] AGPL-3 2021-12-13 application/tgz https://CRAN.R-project.org/package=twosigma doi:10.32614/CRAN.package.twosigma