<?xml version="1.0" encoding="UTF-8"?>
<oai_dc:dc xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:title>Two-/Three-Stage Designs for Phase 1&amp;2 Clinical Trials</dc:title>
  <dc:title>R package tsdf version 1.1-9</dc:title>
  <dc:description>Calculates Zhong's optimal two-/three-stage Phase II designs
    for single-arm trials, generates target-toxicity decision tables for
    two-/three-stage Phase I dose-finding, and supports dose-finding
    simulations using custom decision tables. The Phase II design is based on
    Zhong (2012) &lt;doi:10.1016/j.cct.2012.07.006&gt;.</dc:description>
  <dc:type>Software</dc:type>
  <dc:relation>Suggests: knitr, rmarkdown</dc:relation>
  <dc:creator>Wenchuan Guo &lt;wguo1017@gmail.com&gt;</dc:creator>
  <dc:publisher>Comprehensive R Archive Network (CRAN)</dc:publisher>
  <dc:contributor>Wenchuan Guo [aut, cre],
  Jianan Hui [aut],
  Bob Zhong [aut]</dc:contributor>
  <dc:rights>GPL-2</dc:rights>
  <dc:date>2026-04-26</dc:date>
  <dc:format>application/tgz</dc:format>
  <dc:identifier>https://CRAN.R-project.org/package=tsdf</dc:identifier>
  <dc:identifier>doi:10.32614/CRAN.package.tsdf</dc:identifier>
</oai_dc:dc>
