Clinical Trial Designs in 'rstan' R package trialr version 0.1.6 A collection of clinical trial designs and methods, implemented in 'rstan' and R, including: the Continual Reassessment Method by O'Quigley et al. (1990) <doi:10.2307/2531628>; EffTox by Thall & Cook (2004) <doi:10.1111/j.0006-341X.2004.00218.x>; the two-parameter logistic method of Neuenschwander, Branson & Sponer (2008) <doi:10.1002/sim.3230>; and the Augmented Binary method by Wason & Seaman (2013) <doi:10.1002/sim.5867>; and more. We provide functions to aid model-fitting and analysis. The 'rstan' implementations may also serve as a cookbook to anyone looking to extend or embellish these models. We hope that this package encourages the use of Bayesian methods in clinical trials. There is a preponderance of early phase trial designs because this is where Bayesian methods are used most. If there is a method you would like implemented, please get in touch. Software Depends: R (>= 3.5.0), methods,Rcpp (>= 1.0.1) Imports: rstan (>= 2.18.2), rstantools (>= 1.5.1), rlang (>= 0.4.5), dplyr, purrr, magrittr, stringr, ggplot2, gtools, coda, tidybayes (>= 2.0.3), tibble (>= 3.0.0), binom, MASS LinkingTo: StanHeaders (>= 2.18.1), rstan (>= 2.18.2), BH (>= 1.69.0-1), Rcpp (>= 1.0.1), RcppEigen (>= 0.3.3.5.0), RcppParallel (>= 5.0.2) Suggests: testthat, knitr, rmarkdown, tidyr, ggridges, DiagrammeR Kristian Brock <kristian.brock@gmail.com> Comprehensive R Archive Network (CRAN) Kristian Brock [aut, cre] (ORCID: <https://orcid.org/0000-0002-3921-0166>), Trustees of Columbia University [cph] GPL (>= 3) 2023-03-12 application/tgz https://CRAN.R-project.org/package=trialr doi:10.32614/CRAN.package.trialr