<?xml version="1.0" encoding="UTF-8"?>
<oai_dc:dc xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:title>Isotonic Designs for Phase 1 Trials with Late-Onset Toxicities</dc:title>
  <dc:title>R package titeIR version 0.1.0</dc:title>
  <dc:description>Functions to design phase 1 trials using an isotonic regression based design incorporating time-to-event information. Simulation and design functions are available, which incorporate information about followup and DLTs, and apply isotonic regression to devise estimates of DLT probability.</dc:description>
  <dc:type>Software</dc:type>
  <dc:relation>Imports: Iso</dc:relation>
  <dc:creator>Lee McDaniel &lt;lmcda4@lsuhsc.edu&gt;</dc:creator>
  <dc:publisher>Comprehensive R Archive Network (CRAN)</dc:publisher>
  <dc:contributor>Lee McDaniel [aut, cre]</dc:contributor>
  <dc:rights>GPL-3</dc:rights>
  <dc:date>2018-09-28</dc:date>
  <dc:format>application/tgz</dc:format>
  <dc:identifier>https://CRAN.R-project.org/package=titeIR</dc:identifier>
  <dc:identifier>doi:10.32614/CRAN.package.titeIR</dc:identifier>
</oai_dc:dc>