Facilitate Clinical Trials Analysis Using Natural Cubic Splines R package splinetrials version 0.1.1 Create mixed models with repeated measures using natural cubic splines applied to an observed continuous time variable, as described by Donohue et al. (2023) <doi:10.1002/pst.2285>. Iterate through multiple covariance structure types until one converges. Categorize observed time according to scheduled visits. Perform subgroup analyses. Software Imports: car, cli, dplyr, emmeans, mmrm (>= 0.3.16), rlang, splines Suggests: ggplot2, survival, testthat (>= 3.0.0) Nik Krieger <nikkrieger@gmail.com> Comprehensive R Archive Network (CRAN) Nik Krieger [aut, cre], Daniel Sabanes Bove [ctb], Eli Lilly and Company [cph] Apache License (>= 2) 2026-01-19 application/tgz https://CRAN.R-project.org/package=splinetrials doi:10.32614/CRAN.package.splinetrials