Visualization and Analysis of Spatial Heterogeneity in Spatially-Resolved Gene Expression R package spatialGE version 1.2.2 Visualization and analysis of spatially resolved transcriptomics data. The 'spatialGE' R package provides methods for visualizing and analyzing spatially resolved transcriptomics data, such as 10X Visium, CosMx, or csv/tsv gene expression matrices. It includes tools for spatial interpolation, autocorrelation analysis, tissue domain detection, gene set enrichment, and differential expression analysis using spatial mixed models. Software Imports: arrow, BiocParallel, concaveman, ComplexHeatmap, data.table, DelayedArray, DelayedMatrixStats, dynamicTreeCut, dplyr, EBImage, ggforce, ggplot2, ggpolypath, ggrepel, gstat, GSVA, hdf5r, jpeg, jsonlite, khroma (>= 1.6.0), magrittr, Matrix, MASS, methods, parallel, png, RColorBrewer, Rcpp (>= 1.0.7), readr, readxl, rlang, scales, sctransform, sfsmisc, sf, sp, spaMM, spdep, stats, stringr, tibble, tidyr, utils, uwot, wordspace LinkingTo: Rcpp, RcppEigen, RcppProgress Suggests: curl, geoR, ggpubr, httr, janitor, kableExtra, knitr, msigdbr, progress, rmarkdown, rpart, R.utils, scSpatialSIM, spatstat, SeuratObject, tidyverse, testthat (>= 3.0.0) Oscar Ospina <oscar.ospina@jhmi.edu> Comprehensive R Archive Network (CRAN) Oscar Ospina [aut, cre] (ORCID: <https://orcid.org/0000-0001-5986-4207>), Alex Soupir [aut] (ORCID: <https://orcid.org/0000-0003-1251-9179>), Brooke Fridley [aut] (ORCID: <https://orcid.org/0000-0001-7739-7956>), Satija Lab [cph] (Copyright holder of code fragments from Seurat function FindVariableFeatures) MIT + file LICENSE (https://CRAN.R-project.org/package=spatialGE/LICENSE) 2025-06-04 application/tgz https://CRAN.R-project.org/package=spatialGE doi:10.32614/CRAN.package.spatialGE