<?xml version="1.0" encoding="UTF-8"?>
<oai_dc:dc xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:title>Simulating Oncology Trials using an Illness-Death Model</dc:title>
  <dc:title>R package simIDM version 0.1.1</dc:title>
  <dc:description>Based on the illness-death model a large number of clinical
    trials with oncology endpoints progression-free survival (PFS) and
    overall survival (OS) can be simulated, see Meller, Beyersmann and
    Rufibach (2019) &lt;doi:10.1002/sim.8295&gt;.  The simulation set-up allows
    for random and event-driven censoring, an arbitrary number of
    treatment arms, staggered study entry and drop-out.  Exponentially,
    Weibull and piecewise exponentially distributed survival times can be
    generated. The correlation between PFS and OS can be calculated.</dc:description>
  <dc:type>Software</dc:type>
  <dc:relation>Depends: R (&gt;= 3.6)</dc:relation>
  <dc:relation>Imports: checkmate, furrr, future, mstate, parallelly, stats, survival</dc:relation>
  <dc:relation>Suggests: coxphw, knitr, mvna, prodlim, rmarkdown, rpact, testthat (&gt;=
3.0.0)</dc:relation>
  <dc:creator>Daniel Sabanés Bové &lt;daniel.sabanes_bove@rconis.com&gt;</dc:creator>
  <dc:publisher>Comprehensive R Archive Network (CRAN)</dc:publisher>
  <dc:contributor>Alexandra Erdmann [aut],
  Daniel Sabanés Bové [aut, cre],
  Kaspar Rufibach [aut],
  Holger Löwe [aut],
  F. Hoffmann-La Roche AG [cph, fnd],
  University of Ulm [cph, fnd]</dc:contributor>
  <dc:rights>Apache License 2.0</dc:rights>
  <dc:date>2026-07-08</dc:date>
  <dc:format>application/tgz</dc:format>
  <dc:identifier>https://CRAN.R-project.org/package=simIDM</dc:identifier>
  <dc:identifier>doi:10.32614/CRAN.package.simIDM</dc:identifier>
  <dc:language>en-US</dc:language>
</oai_dc:dc>
