<?xml version="1.0" encoding="UTF-8"?>
<oai_dc:dc xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:title>Extract, Analyze and Visualize Mutational Signatures for Genomic
Variations</dc:title>
  <dc:title>R package sigminer version 2.3.1</dc:title>
  <dc:subject>CRAN Task View: Omics (https://CRAN.R-project.org/view=Omics)</dc:subject>
  <dc:description>Genomic alterations including single nucleotide substitution,
    copy number alteration, etc. are the major force for cancer
    initialization and development. Due to the specificity of molecular
    lesions caused by genomic alterations, we can generate characteristic
    alteration spectra, called 'signature' (Wang, Shixiang, et al. (2021)
    &lt;DOI:10.1371/journal.pgen.1009557&gt; &amp; Alexandrov, Ludmil B., et al.
    (2020) &lt;DOI:10.1038/s41586-020-1943-3&gt; &amp; Steele Christopher D., et al.
    (2022) &lt;DOI:10.1038/s41586-022-04738-6&gt;).  This package helps users to
    extract, analyze and visualize signatures from genomic alteration
    records, thus providing new insight into cancer study.</dc:description>
  <dc:type>Software</dc:type>
  <dc:relation>Depends: R (&gt;= 3.5)</dc:relation>
  <dc:relation>Imports: cli (&gt;= 2.0.0), cowplot, data.table, dplyr, furrr (&gt;= 0.2.0),
future, ggplot2 (&gt;= 3.3.0), ggpubr, maftools, magrittr,
methods, NMF, purrr, Rcpp, rlang (&gt;= 0.1.2), stats, tidyr</dc:relation>
  <dc:relation>LinkingTo: Rcpp</dc:relation>
  <dc:relation>Suggests: Biobase, Biostrings, BSgenome, BSgenome.Hsapiens.UCSC.hg19,
circlize, cluster, covr, digest, GenomicRanges, GenSA,
ggalluvial, ggcorrplot, ggfittext, ggplotify, ggrepel, IRanges,
knitr, lpSolve, markdown, matrixStats, nnls, parallel,
patchwork, pheatmap, quadprog, R.utils, RColorBrewer,
reticulate, rmarkdown, roxygen2, scales, synchronicity,
testthat (&gt;= 3.0.0), tibble, UCSCXenaTools</dc:relation>
  <dc:creator>Shixiang Wang &lt;w_shixiang@163.com&gt;</dc:creator>
  <dc:publisher>Comprehensive R Archive Network (CRAN)</dc:publisher>
  <dc:contributor>Shixiang Wang [aut, cre] (ORCID:
    &lt;https://orcid.org/0000-0001-9855-7357&gt;),
  Ziyu Tao [aut] (ORCID: &lt;https://orcid.org/0000-0003-3272-1227&gt;),
  Huimin Li [aut] (ORCID: &lt;https://orcid.org/0000-0003-1683-9057&gt;),
  Tao Wu [aut] (ORCID: &lt;https://orcid.org/0000-0002-8999-9628&gt;),
  Xue-Song Liu [aut, ctb] (ORCID:
    &lt;https://orcid.org/0000-0002-7736-0077&gt;),
  Anand Mayakonda [ctb]</dc:contributor>
  <dc:rights>MIT + file LICENSE (https://CRAN.R-project.org/package=sigminer/LICENSE)</dc:rights>
  <dc:date>2024-05-11</dc:date>
  <dc:format>application/tgz</dc:format>
  <dc:identifier>https://CRAN.R-project.org/package=sigminer</dc:identifier>
  <dc:identifier>doi:10.32614/CRAN.package.sigminer</dc:identifier>
</oai_dc:dc>