RNA-Seq Generation/Modification for Simulation R package seqgendiff version 1.2.4 CRAN Task View: Omics (https://CRAN.R-project.org/view=Omics) Generates/modifies RNA-seq data for use in simulations. We provide a suite of functions that will add a known amount of signal to a real RNA-seq dataset. The advantage of using this approach over simulating under a theoretical distribution is that common/annoying aspects of the data are more preserved, giving a more realistic evaluation of your method. The main functions are select_counts(), thin_diff(), thin_lib(), thin_gene(), thin_2group(), thin_all(), and effective_cor(). See Gerard (2020) <doi:10.1186/s12859-020-3450-9> for details on the implemented methods. Software Imports: assertthat, irlba, sva, pdist, matchingR, clue Suggests: covr, testthat (>= 2.1.0), SummarizedExperiment, DESeq2, knitr, rmarkdown, airway, limma, qvalue, edgeR David Gerard <gerard.1787@gmail.com> Comprehensive R Archive Network (CRAN) David Gerard [aut, cre] (ORCID: <https://orcid.org/0000-0001-9450-5023>) GPL-3 2024-05-15 application/tgz https://CRAN.R-project.org/package=seqgendiff doi:10.32614/CRAN.package.seqgendiff