<?xml version="1.0" encoding="UTF-8"?>
<oai_dc:dc xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:title>Estimate Ploidy and Absolute Copy Number from Single Cell
Sequencing</dc:title>
  <dc:title>R package scquantum version 1.0.0</dc:title>
  <dc:description>Given bincount data from single-cell copy number profiling (segmented or unsegmented), estimates ploidy, and uses the ploidy estimate to scale the data to absolute copy numbers. Uses the modular quantogram proposed by Kendall (1986) &lt;doi:10.1002/0471667196.ess2129.pub2&gt;, modified by weighting segments according to confidence, and quantifying confidence in the estimate using a theoretical quantogram. Includes optional fused-lasso segmentation with the algorithm in Johnson (2013) &lt;doi:10.1080/10618600.2012.681238&gt;, using the implementation from glmgen by Arnold, Sadhanala, and Tibshirani.</dc:description>
  <dc:type>Software</dc:type>
  <dc:relation>Suggests: testthat (&gt;= 3.0.0)</dc:relation>
  <dc:creator>Alexander Davis &lt;alexlovesmolecules@gmail.com&gt;</dc:creator>
  <dc:publisher>Comprehensive R Archive Network (CRAN)</dc:publisher>
  <dc:contributor>Alexander Davis [aut, cre],
  Taylor Arnold [cph] (Author of segmentation function),
  Veeranjaneyulu Sadhanala [cph] (Author of segmentation function),
  Ryan Tibshirani [cph] (Author of segmentation function)</dc:contributor>
  <dc:rights>GPL (&gt;= 2)</dc:rights>
  <dc:date>2022-03-23</dc:date>
  <dc:format>application/tgz</dc:format>
  <dc:identifier>https://CRAN.R-project.org/package=scquantum</dc:identifier>
  <dc:identifier>doi:10.32614/CRAN.package.scquantum</dc:identifier>
</oai_dc:dc>
