Optimization Toolkit for Pharmacokinetic-Pharmacodynamic Models R package scaRabee version 1.1-5 CRAN Task View: Pharmacokinetics (https://CRAN.R-project.org/view=Pharmacokinetics) A port of the Scarabee toolkit originally written as a Matlab-based application. scaRabee provides a framework for simulation and optimization of pharmacokinetic-pharmacodynamic models at the individual and population level. It is built on top of the neldermead package, which provides the direct search algorithm proposed by Nelder and Mead for model optimization. Software Depends: neldermead (>= 1.0-8), optimsimplex (>= 1.0-5), optimbase (>= 1.0-8) Imports: lattice, grid, deSolve, utils, methods Suggests: knitr (>= 1.28),rmarkdown (>= 2.2) Sebastien Bihorel <sb.pmlab@gmail.com> Comprehensive R Archive Network (CRAN) Sebastien Bihorel [aut, cre] GPL-3 2026-01-25 application/tgz https://CRAN.R-project.org/package=scaRabee doi:10.32614/CRAN.package.scaRabee