Confirmatory Adaptive Clinical Trial Design and Analysis R package rpact version 4.4.0 CRAN Task View: ClinicalTrials (https://CRAN.R-project.org/view=ClinicalTrials) Design and analysis of confirmatory adaptive clinical trials with continuous, binary, and survival endpoints according to the methods described in the monograph by Wassmer and Brannath (2025) <doi:10.1007/978-3-031-89669-9>. This includes classical group sequential as well as multi-stage adaptive hypotheses tests that are based on the combination testing principle. Software Depends: R (>= 3.6.0) Imports: methods, stats, utils, graphics, tools, rlang, R6 (>= 2.5.1), knitr (>= 1.19), Rcpp (>= 1.0.3) LinkingTo: Rcpp Suggests: ggplot2 (>= 3.5.0), testthat (>= 3.0.0), rmarkdown (>= 1.10), rappdirs (>= 0.3.3) Friedrich Pahlke <friedrich.pahlke@rpact.com> Comprehensive R Archive Network (CRAN) Gernot Wassmer [aut] (ORCID: <https://orcid.org/0000-0001-9397-1794>), Friedrich Pahlke [aut, cre] (ORCID: <https://orcid.org/0000-0003-2105-2582>), Till Jensen [ctb], Daniel Sabanes Bove [ctb] (ORCID: <https://orcid.org/0000-0002-0176-9239>), Stephen Schueuerhuis [ctb] (ORCID: <https://orcid.org/0009-0006-3124-6056>), Tobias Muetze [ctb] (ORCID: <https://orcid.org/0000-0002-4111-1941>), RPACT GmbH [cph, fnd] LGPL-3 2026-03-04 application/tgz https://CRAN.R-project.org/package=rpact doi:10.32614/CRAN.package.rpact en-US