<?xml version="1.0" encoding="UTF-8"?>
<oai_dc:dc xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:title>Query Composite Hypotheses</dc:title>
  <dc:title>R package qch version 2.1.3</dc:title>
  <dc:description>Provides functions for the joint analysis of Q sets of
    p-values obtained for the same list of items. This joint analysis is
    performed by querying a composite hypothesis, i.e. an arbitrary
    complex combination of simple hypotheses, as described in Mary-Huard
    et al. (2021) &lt;doi:10.1093/bioinformatics/btab592&gt; and De Walsche et
    al.(2025) &lt;doi: 10.1093/nargab/lqaf118&gt;. In this approach, the Q-uplet
    of p-values associated with each item is distributed as a multivariate
    mixture, where each of the 2^Q components corresponds to a specific
    combination of simple hypotheses. The dependence between the p-value
    series is considered using a Gaussian copula function. A p-value for
    the composite hypothesis test is derived from the posterior
    probabilities.</dc:description>
  <dc:type>Software</dc:type>
  <dc:relation>Depends: R (&gt;= 2.10)</dc:relation>
  <dc:relation>Imports: copula, dplyr, graphics, ks, purrr, Rcpp, stats, stringr,
utils</dc:relation>
  <dc:relation>LinkingTo: Rcpp, RcppArmadillo</dc:relation>
  <dc:creator>Tristan Mary-Huard &lt;tristan.mary-huard@agroparistech.fr&gt;</dc:creator>
  <dc:publisher>Comprehensive R Archive Network (CRAN)</dc:publisher>
  <dc:contributor>Tristan Mary-Huard [aut, cre] (ORCID:
    &lt;https://orcid.org/0000-0002-3839-9067&gt;),
  Annaig De Walsche [aut] (ORCID:
    &lt;https://orcid.org/0000-0003-0603-1716&gt;),
  Franck Gauthier [ctb] (ORCID: &lt;https://orcid.org/0000-0003-0574-065X&gt;)</dc:contributor>
  <dc:rights>GPL-3</dc:rights>
  <dc:date>2026-05-27</dc:date>
  <dc:format>application/tgz</dc:format>
  <dc:identifier>https://CRAN.R-project.org/package=qch</dc:identifier>
  <dc:identifier>doi:10.32614/CRAN.package.qch</dc:identifier>
</oai_dc:dc>
