Application of NODEs in 'Monolix', 'NONMEM', and 'nlmixr2' R package pmxNODE version 0.1.0 An easy-to-use tool for implementing Neural Ordinary Differential Equations (NODEs) in pharmacometric software such as 'Monolix', 'NONMEM', and 'nlmixr2', see Bräm et al. (2024) <doi:10.1007/s10928-023-09886-4> and Bräm et al. (2025) <doi:10.1002/psp4.13265>. The main functionality is to automatically generate structural model code describing computations within a neural network. Additionally, parameters and software settings can be initialized automatically. For using these additional functionalities with 'Monolix', 'pmxNODE' interfaces with 'MonolixSuite' via the 'lixoftConnectors' package. The 'lixoftConnectors' package is distributed with 'MonolixSuite' (<https://monolixsuite.slp-software.com/r-functions/2024R1/package-lixoftconnectors>) and is not available from public repositories. Software Imports: tidyr, ggplot2, checkmate Suggests: rxode2, nlmixr2, lixoftConnectors, withr, testthat (>= 3.0.0), knitr, rmarkdown Dominic Bräm <domi.braem@hotmail.com> Comprehensive R Archive Network (CRAN) Dominic Bräm [aut, cre] (ORCID: <https://orcid.org/0000-0001-9094-8361>), Bernhard Steiert [ctb], Gilbert Koch [ctb], Matthew Fidler [ctb] (ORCID: <https://orcid.org/0000-0001-8538-6691>) GPL (>= 3) 2025-11-26 application/tgz https://CRAN.R-project.org/package=pmxNODE doi:10.32614/CRAN.package.pmxNODE