Global Sensitivity Analysis in Physiologically Based Kinetic Modeling R package pksensi version 1.2.3 Applying the global sensitivity analysis workflow to investigate the parameter uncertainty and sensitivity in physiologically based kinetic (PK) models, especially the physiologically based pharmacokinetic/toxicokinetic model with multivariate outputs. The package also provides some functions to check the convergence and sensitivity of model parameters. The workflow was first mentioned in Hsieh et al., (2018) <doi:10.3389/fphar.2018.00588>, then further refined (Hsieh et al., 2020 <doi:10.1016/j.softx.2020.100609>). Software Depends: R (>= 4.1) Imports: ggplot2, data.table, deSolve, foreach, parallel, doParallel Suggests: covr, knitr, httk, rmarkdown, testthat Nan-Hung Hsieh <d99622005@ntu.edu.tw> Comprehensive R Archive Network (CRAN) Nan-Hung Hsieh [aut, cre] (ORCID: <https://orcid.org/0000-0003-0163-2766>), Brad Reisfeld [ctb] (ORCID: <https://orcid.org/0000-0003-1310-1495>), Weihsueh A. Chiu [ctb] (ORCID: <https://orcid.org/0000-0002-7575-2368>) GPL-3 file LICENSE (https://CRAN.R-project.org/package=pksensi/LICENSE) 2022-09-21 application/tgz https://CRAN.R-project.org/package=pksensi doi:10.32614/CRAN.package.pksensi en-US