Nonlinear Mixed Effects Models in Population PK/PD R package nlmixr2 version 5.0.0 CRAN Task View: DifferentialEquations (https://CRAN.R-project.org/view=DifferentialEquations) CRAN Task View: HighPerformanceComputing (https://CRAN.R-project.org/view=HighPerformanceComputing) CRAN Task View: MixedModels (https://CRAN.R-project.org/view=MixedModels) CRAN Task View: Pharmacokinetics (https://CRAN.R-project.org/view=Pharmacokinetics) Fit and compare nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation solving is by compiled C code provided in the 'rxode2' package (Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>). Software Imports: cli (>= 1.0.0), crayon (>= 1.3.4), dplyr (>= 0.7.4), purrr (>= 0.2.4), rstudioapi (>= 0.7), nlmixr2est (>= 5.0.0), nlmixr2extra (>= 5.0.0), rxode2 (>= 5.0.0), lotri (>= 0.4.3), nlmixr2plot (>= 5.0.0), tibble, magrittr Suggests: rmarkdown, knitr, devtools, ggplot2, testthat, n1qn1, withr Matthew Fidler <matthew.fidler@gmail.com> Comprehensive R Archive Network (CRAN) Matthew Fidler [aut, cre] (ORCID: <https://orcid.org/0000-0001-8538-6691>), Anne Keunecke [ctb], Rik Schoemaker [ctb] (ORCID: <https://orcid.org/0000-0002-7538-3005>), Justin Wilkins [ctb] (ORCID: <https://orcid.org/0000-0002-7099-9396>), Wenping Wang [ctb], Mirjam Trame [ctb], John Harrold [ctb], Bill Denney [ctb] (ORCID: <https://orcid.org/0000-0002-5759-428X>), Theodoros Papathanasiou [ctb], Richard Hooijmaijers [ctb], Michael Wayne Kearney [ctb] (ORCID: <https://orcid.org/0000-0002-0730-4694>) GPL (>= 3) 2025-11-30 application/tgz https://CRAN.R-project.org/package=nlmixr2 doi:10.32614/CRAN.package.nlmixr2