MEchanistic Clustering - Treatment eXposure Framework R package mectx version 1.1.1 Implements the MEC-TX (MEchanistic Clustering - Treatment eXposure) framework for encoding, clustering, and survival analysis of real-world oncology treatment timelines. Provides functions for normalising medication records, computing treatment intervals, performing k-means clustering in PCA space, assigning line-of-therapy labels, and comparing survival outcomes across treatment groups. Designed for use with registry-based cohorts such as the ORIEN AVATAR dataset. Methods follow the digital-twin framework described in Dhrubo and Spakowicz (2026) <https://github.com/spakowiczlab/mec-tx>. treatment timelines using the MEC-TX digital-twin framework. Software Depends: R (>= 4.4.0) Imports: magrittr, broom, dplyr, forcats, ggnewscale, ggplot2, patchwork, purrr, stats, stringr, survival, tibble, tidyr, umap Suggests: testthat (>= 3.0.0), devtools, roxygen2 Dipankor Dhrubo <dhrubo.2@osu.edu> Comprehensive R Archive Network (CRAN) Dipankor Dhrubo [aut, cre], Daniel Spakowicz [aut] (ORCID: <https://orcid.org/0000-0003-2314-6435>) MIT + file LICENSE (https://CRAN.R-project.org/package=mectx/LICENSE) 2026-05-11 application/tgz https://CRAN.R-project.org/package=mectx doi:10.32614/CRAN.package.mectx en-US