<?xml version="1.0" encoding="UTF-8"?>
<oai_dc:dc xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:title>Joint Modelling of Multivariate Longitudinal Data and
Time-to-Event Outcomes</dc:title>
  <dc:title>R package joineRML version 0.4.8</dc:title>
  <dc:subject>CRAN Task View: Survival (https://CRAN.R-project.org/view=Survival)</dc:subject>
  <dc:description>Fits the joint model proposed by Henderson and colleagues (2000) 
    &lt;doi:10.1093/biostatistics/1.4.465&gt;, but extended to the case of multiple 
    continuous longitudinal measures. The time-to-event data is modelled using a 
    Cox proportional hazards regression model with time-varying covariates. The 
    multiple longitudinal outcomes are modelled using a multivariate version of the 
    Laird and Ware linear mixed model. The association is captured by a multivariate
    latent Gaussian process. The model is estimated using a Monte Carlo Expectation 
    Maximization algorithm. This project was funded by the Medical Research Council 
    (Grant number MR/M013227/1).</dc:description>
  <dc:type>Software</dc:type>
  <dc:relation>Depends: R (&gt;= 4.1.0), nlme, survival</dc:relation>
  <dc:relation>Imports: cobs, doParallel, foreach, generics, ggplot2, graphics, lme4
(&gt;= 1.1-8), MASS, Matrix, mvtnorm, parallel, randtoolbox, Rcpp
(&gt;= 0.12.7), RcppArmadillo, stats, tibble, utils</dc:relation>
  <dc:relation>LinkingTo: Rcpp, RcppArmadillo</dc:relation>
  <dc:relation>Suggests: dplyr, JM, joineR, knitr, pkgdown, rmarkdown, testthat (&gt;=
3.0.0)</dc:relation>
  <dc:creator>Graeme L. Hickey &lt;graemeleehickey@gmail.com&gt;</dc:creator>
  <dc:publisher>Comprehensive R Archive Network (CRAN)</dc:publisher>
  <dc:contributor>Graeme L. Hickey [cre, aut] (ORCID:
    &lt;https://orcid.org/0000-0002-4989-0054&gt;),
  Pete Philipson [aut] (ORCID: &lt;https://orcid.org/0000-0001-7846-0208&gt;),
  Andrea Jorgensen [ctb] (ORCID: &lt;https://orcid.org/0000-0002-6977-9337&gt;),
  Ruwanthi Kolamunnage-Dona [aut] (ORCID:
    &lt;https://orcid.org/0000-0003-3886-6208&gt;),
  Paula Williamson [ctb] (ORCID: &lt;https://orcid.org/0000-0001-9802-6636&gt;),
  Dimitris Rizopoulos [ctb, dtc] (data/renal.rda, R/hessian.R, R/vcov.R),
  Alessandro Gasparini [aut] (ORCID:
    &lt;https://orcid.org/0000-0002-8319-7624&gt;),
  Medical Research Council [fnd] (Grant number: MR/M013227/1)</dc:contributor>
  <dc:rights>GPL-3</dc:rights>
  <dc:rights>file LICENSE (https://CRAN.R-project.org/package=joineRML/LICENSE)</dc:rights>
  <dc:date>2026-06-14</dc:date>
  <dc:format>application/tgz</dc:format>
  <dc:identifier>https://CRAN.R-project.org/package=joineRML</dc:identifier>
  <dc:identifier>doi:10.32614/CRAN.package.joineRML</dc:identifier>
</oai_dc:dc>
