GWAS-to-CRISPR Data Pipeline for High-Throughput SNP Target Extraction R package gwas2crispr version 0.1.5 Provides a reproducible pipeline to conduct genome-wide association studies (GWAS) and extract single-nucleotide polymorphisms (SNPs) for a human trait or disease. Given aggregated GWAS dataset(s) and a user-defined significance threshold, the package retrieves significant SNPs from the GWAS Catalog using supported trait identifiers, annotates their gene context, and can write a harmonised metadata table in comma-separated values (CSV) format, genomic intervals in the Browser Extensible Data (BED) format, and sequences in the FASTA (text-based sequence) format with user-defined flanking regions for clustered regularly interspaced short palindromic repeats (CRISPR) guide design. The existing efo_id argument is retained for backward compatibility. The package prepares computational artifacts for downstream workflows; it does not perform biological causality testing, clinical interpretation, therapeutic design, or wet-lab validation. For details on the resources and methods see: Buniello et al. (2019) <doi:10.1093/nar/gky1120>; Sollis et al. (2023) <doi:10.1093/nar/gkac1010>; Jinek et al. (2012) <doi:10.1126/science.1225829>. Software Depends: R (>= 4.1) Imports: httr, dplyr, purrr, tibble, tidyr, readr, stringr, tidyselect Suggests: Biostrings, BSgenome.Hsapiens.UCSC.hg38, GenomeInfoDb, optparse, testthat, knitr, rmarkdown Othman S. I. Mohammed <admin@leopard.ly> Comprehensive R Archive Network (CRAN) Othman S. I. Mohammed [aut, cre], LEOPARD.LY LTD [cph] MIT + file LICENSE (https://CRAN.R-project.org/package=gwas2crispr/LICENSE) 2026-06-02 application/tgz https://CRAN.R-project.org/package=gwas2crispr doi:10.32614/CRAN.package.gwas2crispr en-US