<?xml version="1.0" encoding="UTF-8"?>
<oai_dc:dc xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:title>Frequentist Dynamic Borrowing for Hybrid-Control Survival Trials</dc:title>
  <dc:title>R package fdb version 0.2.0</dc:title>
  <dc:description>Implements a class of likelihood-informed frequentist dynamic
    borrowing methods for hybrid-control survival trials based on penalized
    Cox partial likelihood estimation. Implements four
    likelihood-informed penalty structures (precision-weighted L1,
    smoothed integrated-gate, information-adaptive minimax concave penalty
    (MCP), and likelihood-ratio-weighted L1), together with the adaptive
    lasso borrowing approach of Li et al. (2023, &lt;doi:10.1002/bimj.202100406&gt;).
    Provides conditional model-based standard errors and local plug-in
    sandwich variance approximations, with smoothed penalties. Tools for design-stage lambda calibration
    via simulation, including a two-stage coarse-fine grid search, drift-level
    early stopping, and per-method tuning under both inference types, are also
    provided. A simulation harness for evaluating type I error and statistical
    power across population drift scenarios is included.</dc:description>
  <dc:type>Software</dc:type>
  <dc:relation>Depends: R (&gt;= 3.6.0)</dc:relation>
  <dc:relation>Imports: survival, stats, parallel, utils</dc:relation>
  <dc:relation>Suggests: testthat (&gt;= 3.0.0), knitr, rmarkdown</dc:relation>
  <dc:creator>Yusuke Yamaguchi &lt;yamagubed@gmail.com&gt;</dc:creator>
  <dc:publisher>Comprehensive R Archive Network (CRAN)</dc:publisher>
  <dc:contributor>Yusuke Yamaguchi [aut, cre]</dc:contributor>
  <dc:rights>MIT + file LICENSE (https://CRAN.R-project.org/package=fdb/LICENSE)</dc:rights>
  <dc:date>2026-10-04</dc:date>
  <dc:format>application/tgz</dc:format>
  <dc:identifier>https://CRAN.R-project.org/package=fdb</dc:identifier>
  <dc:identifier>doi:10.32614/CRAN.package.fdb</dc:identifier>
</oai_dc:dc>
