A Modular Approach to Dose-Finding Clinical Trials R package escalation version 0.2.3 CRAN Task View: ClinicalTrials (https://CRAN.R-project.org/view=ClinicalTrials) Methods for working with dose-finding clinical trials. We provide implementations of many dose-finding clinical trial designs, including the continual reassessment method (CRM) by O'Quigley et al. (1990) <doi:10.2307/2531628>, the toxicity probability interval (TPI) design by Ji et al. (2007) <doi:10.1177/1740774507079442>, the modified TPI (mTPI) design by Ji et al. (2010) <doi:10.1177/1740774510382799>, the Bayesian optimal interval design (BOIN) by Liu & Yuan (2015) <doi:10.1111/rssc.12089>, EffTox by Thall & Cook (2004) <doi:10.1111/j.0006-341X.2004.00218.x>; the design of Wages & Tait (2015) <doi:10.1080/10543406.2014.920873>, and the 3+3 described by Korn et al. (1994) <doi:10.1002/sim.4780131802>. All designs are implemented with a common interface. We also offer optional additional classes to tailor the behaviour of all designs, including avoiding skipping doses, stopping after n patients have been treated at the recommended dose, stopping when a toxicity condition is met, or demanding that n patients are treated before stopping is allowed. By daisy-chaining together these classes using the pipe operator from 'magrittr', it is simple to tailor the behaviour of a dose-finding design so it behaves how the trialist wants. Having provided a flexible interface for specifying designs, we then provide functions to run simulations and calculate dose-paths for future cohorts of patients. Software Depends: magrittr Imports: dplyr, tidyr (>= 1.0), tidyselect, stringr, purrr, tibble, ggplot2, gtools, dfcrm, BOIN, trialr (>= 0.1.5), DiagrammeR, RColorBrewer, viridis, binom, R6, mvtnorm, graphics, Iso, testthat Suggests: knitr, rmarkdown, covr Kristian Brock <kristian.brock@gmail.com> Comprehensive R Archive Network (CRAN) Kristian Brock [aut, cre] (ORCID: <https://orcid.org/0000-0002-3921-0166>), Daniel Slade [aut] (ORCID: <https://orcid.org/0000-0001-6063-1283>), Michael Sweeting [aut] (ORCID: <https://orcid.org/0000-0003-0980-8965>), Conor Norris [ctb] (ORCID: <https://orcid.org/0009-0009-8850-0811>), Bharat Bhushan [ctb] (ORCID: <https://orcid.org/0009-0001-5271-7113>) GPL (>= 3) 2025-10-08 application/tgz https://CRAN.R-project.org/package=escalation doi:10.32614/CRAN.package.escalation