Lipid Set Enrichment Analysis with Dual KS and 'fgsea' Engines R package easyLSEA version 0.2.1 Provides biology-aware lipid set enrichment analysis (LSEA) for lipidomics data using dual engines: the Kolmogorov-Smirnov test and the fast gene set enrichment algorithm from the 'fgsea' package. Annotates lipids into biological groups at three levels (lipid class, LIPID MAPS category, functional category) and tests for coordinated directional shifts between conditions. Includes fatty acid chain analysis with trend plots weighted by lipid abundance (Spearman rank correlation, configurable smoothing), wide-format chain position output (sn-1, sn-2, sn-3, sn-4), annotation confidence filtering, and export utilities for reproducible reporting in CSV, 'Excel', and PDF formats. Vignettes are available in English and Spanish. Methods are based on Subramanian et al. (2005) <doi:10.1073/pnas.0506580102> and Korotkevich et al. (2021) <doi:10.1101/060012>. Software Depends: R (>= 4.1.0) Imports: ggplot2, withr Suggests: fgsea, knitr, openxlsx, rmarkdown, spelling, testthat (>= 3.0.0) David Guardamino Ojeda <david.guardamino@gmail.com> Comprehensive R Archive Network (CRAN) David Guardamino Ojeda [aut, cre] (ORCID: <https://orcid.org/0000-0002-3122-2218>) MIT + file LICENSE (https://CRAN.R-project.org/package=easyLSEA/LICENSE) 2026-06-16 application/tgz https://CRAN.R-project.org/package=easyLSEA doi:10.32614/CRAN.package.easyLSEA en-US