Statistical Analyses of De Novo Genetic Variants R package denovolyzeR version 0.2.0 An integrated toolset for the analysis of de novo (sporadic) genetic sequence variants. denovolyzeR implements a mutational model that estimates the probability of a de novo genetic variant arising in each human gene, from which one can infer the expected number of de novo variants in a given population size. Observed variant frequencies can then be compared against expectation in a Poisson framework. denovolyzeR provides a suite of functions to implement these analyses for the interpretation of de novo variation in human disease. Software Depends: R (>= 3.1.0) Imports: dplyr (>= 0.3), reshape2 (>= 1.4) Suggests: knitr, rmarkdown James Ware <j.ware@imperial.ac.uk> Comprehensive R Archive Network (CRAN) James Ware [aut, cre], Jason Homsy [ctb], Kaitlin Samocha [ctb] GPL-3 2016-08-01 application/tgz https://CRAN.R-project.org/package=denovolyzeR doi:10.32614/CRAN.package.denovolyzeR