Quantifies submission risk using a Failure Modes and Effects
    Analysis (FMEA)-inspired framework (probability, impact, detectability).
    Builds risk registers from evidence, computes Risk Priority Numbers (RPN),
    classifies risk levels, and emits standardized R4SUB (R for Regulatory
    Submission) evidence table rows via 'r4subcore'. Supports risk mitigation
    tracking and trend analysis across submission milestones.

Converts standardized R4SUB (R for Regulatory Submission) evidence
    into indicator scores, pillar scores, and a Submission Confidence Index
    (SCI). Provides sensitivity analysis, explainability tables, and decision
    band classification to answer the question: are we ready for regulatory
    submission.

Quantifies and explains end-to-end traceability between clinical
    submission artifacts (ADaM (Analysis Data Model) outputs, derivations,
    SDTM (Study Data Tabulation Model) sources, specs, code). Builds trace
    models from metadata and mapping sheets, computes trace levels, and emits
    standardized R4SUB (R for Regulatory Submission) evidence table rows via
    'r4subcore'.

Rapid realistic routing on multimodal transport networks
    (walk, bike, public transport and car) using 'R5', the Rapid Realistic
    Routing on Real-world and Reimagined networks engine
    <https://github.com/conveyal/r5>. The package allows users to generate
    detailed routing analysis or calculate travel time and monetary cost matrices 
    using seamless parallel computing on top of the R5 Java machine.  While R5
    is developed by Conveyal, the package r5r is independently developed
    by a team at the Institute for Applied Economic Research (Ipea) with
    contributions from collaborators. Apart from the documentation in this
    package, users will find additional information on R5 documentation at
    <https://docs.conveyal.com/>. Although we try to keep new releases of
    r5r in synchrony with R5, the development of R5 follows Conveyal's
    independent update process. Hence, users should confirm the R5 version
    implied by the Conveyal user manual (see
    <https://docs.conveyal.com/changelog>) corresponds with the R5 version
    that r5r depends on. This version of r5r depends on R5 v7.1.