It provides functions to generate operating characteristics and to calculate Sequential Conditional Probability Ratio Tests(SCPRT) efficacy and futility boundary values along with sample/event size of Multi-Arm Multi-Stage(MAMS) trials for different outcomes. The package is based on Jianrong Wu, Yimei Li, Liang Zhu (2023) <doi:10.1002/sim.9682>, Jianrong Wu, Yimei Li (2023) "Group Sequential Multi-Arm Multi-Stage Survival Trial Design with Treatment Selection"(Manuscript accepted for publication) and Jianrong Wu, Yimei Li, Shengping Yang (2023) "Group Sequential Multi-Arm Multi-Stage Trial Design with Ordinal Endpoints"(In preparation).

Simulating composite endpoints with recurrent and terminal events under staggered entry, and for constructing one- and two-sample group sequential test statistics and monitoring boundaries based on the mean frequency function. Details will be available in an upcoming publication.

Estimating trait heritability and handling overfitting. This package includes a collection of functions for (1) estimating genetic variance-covariances and calculate trait heritability; and (2) handling overfitting by calculating the variance components and the heritability through cross validation.

Provides automated downloading, parsing, cleaning, unit
    conversion and formatting of Global Surface Summary of the Day
    ('GSOD') weather data from the from the USA National Centers for
    Environmental Information ('NCEI').  The data were retired on
    2025-08-29 and are no longer updated. Units are converted from from
    United States Customary System ('USCS') units to International System
    of Units ('SI').  Stations may be individually checked for number of
    missing days defined by the user, where stations with too many missing
    observations are omitted.  Only stations with valid reported latitude
    and longitude values are permitted in the final data.  Additional
    useful elements, saturation vapour pressure ('es'), actual vapour
    pressure ('ea') and relative humidity ('RH') are calculated from the
    original data using the improved August-Roche-Magnus approximation
    (Alduchov & Eskridge 1996) and included in the final data set.  The
    resulting metadata include station identification information,
    country, state, latitude, longitude, elevation, weather observations
    and associated flags.  For information on the 'GSOD' data from 'NCEI',
    please see the 'GSOD' 'readme.txt' file available from,
    <https://www.ncei.noaa.gov/pub/data/gsod/readme.txt>.