The advent of genomic technologies has enabled the generation of two-dimensional or even multi-dimensional high-throughput data, e.g., monitoring multiple changes in gene expression in genome-wide siRNA screens across many different cell types (E Robert McDonald 3rd (2017) <doi: 10.1016/j.cell.2017.07.005> and Tsherniak A (2017) <doi: 10.1016/j.cell.2017.06.010>) or single cell transcriptomics under different experimental conditions. We found that simple computational methods based on a single statistical criterion is no longer adequate for analyzing such multi-dimensional data. We herein introduce 'ZetaSuite', a statistical package initially designed to score hits from two-dimensional RNAi screens.We also illustrate a unique utility of 'ZetaSuite' in analyzing single cell transcriptomics to differentiate rare cells from damaged ones (Vento-Tormo R (2018) <doi: 10.1038/s41586-018-0698-6>). In 'ZetaSuite', we  have the following steps: QC of input datasets, normalization using Z-transformation, Zeta score calculation and hits selection based on defined Screen Strength.

Performs Zoom-Focus Algorithm (ZFA) to optimize testing regions for rare variant association tests in exome sequencing data.

Improve the usage of model fitting functions within a piped
    work flow.

A two-part zero-inflated Beta regression model with random 
    effects (ZIBR) for testing the association between microbial abundance 
    and clinical covariates for longitudinal microbiome data. Eric Z. Chen 
    and Hongzhe Li (2016) <doi:10.1093/bioinformatics/btw308>.

Parameter estimation for zero-inflated discrete Weibull (ZIDW) regression models, the univariate setting, distribution functions, functions to generate randomized quantile residuals a pseudo R2, and plotting of rootograms. For more details, see Kalktawi (2017)  <https://bura.brunel.ac.uk/handle/2438/14476>, Taconeli and Rodrigues de Lara (2022) <doi:10.1080/00949655.2021.2005597>, and Yeh and Young (2025) <doi:10.1080/03610918.2025.2464076>.