Tools for smoothing and tidying spatial features
    (i.e. lines and polygons) to make them more aesthetically pleasing.
    Smooth curves, fill holes, and remove small fragments from lines and
    polygons.

Computes smooth estimations for the Cumulative/Dynamic and Incident/Dynamic ROC curves, in presence of right censorship, based on the bivariate kernel density estimation of the joint distribution function of the Marker and Time-to-event variables.

Contains, as a main contribution, a function to fit
             a regression model with possibly right, left or interval
             censored observations and with the error distribution
             expressed as a mixture of G-splines. Core part
             of the computation is done in compiled 'C++' written
             using the 'Scythe' Statistical Library Version 0.3.

Given independent and identically distributed observations X(1), ..., X(n) from a Generalized Pareto distribution with shape parameter gamma in [-1,0], offers several estimates to compute estimates of gamma. The estimates are based on the principle of replacing the order statistics by quantiles of a distribution function based on a log--concave density function. This procedure is justified by the fact that the GPD density is log--concave for gamma in [-1,0].

Fits symmetric soft windowing to linear and non-linear models by assigning exponential weights over time around specified modes; bandwidth and sharpness of the windows are chosen by a grid search and comparison diagnostics (Hamed Haselimashhadi et al (2019) <doi:10.1093/bioinformatics/btz744>).

A flexible moving average algorithm for modeling drug exposure in pharmacoepidemiology studies as presented in the article: Ouchi, D.,  Giner-Soriano, M., Gómez-Lumbreras, A., Vedia Urgell, C.,Torres, F., & Morros, R. (2022). "Automatic Estimation of the Most Likely Drug Combination in Electronic Health Records Using the Smooth Algorithm : Development and Validation Study." JMIR medical informatics, 10(11), e37976. <doi:10.2196/37976>.