A protocol that facilitates the processing and analysis of Hydrogen-Deuterium Exchange Mass Spectrometry data using p-value statistics and Critical Interval analysis. 
    It provides a pipeline for analyzing data from 'HDXExaminer' (Sierra Analytics, Trajan Scientific), 
    automating matching and comparison of protein states through Welch's T-test and the Critical Interval statistical framework. 
    Additionally, it simplifies data export, generates 'PyMol' scripts, and ensures calculations meet publication standards. 
    'HDXBoxeR' assists in various aspects of hydrogen-deuterium exchange data analysis, including reprocessing data, calculating parameters, identifying significant peptides, 
    generating plots, and facilitating comparison between protein states. 
    For details check papers by Hageman and Weis (2019) <doi:10.1021/acs.analchem.9b01325> 
    and Masson et al. (2019) <doi:10.1038/s41592-019-0459-y>.
    'HDXBoxeR' citation: Janowska et al. (2024) <doi:10.1093/bioinformatics/btae479>.

Create dynamic, data-driven text. Given two values, a list of 
    talking points is generated and can be combined using string
    interpolation. Based on the 'glue' package.

Allows for painless use of the 'Metopio' health atlas APIs
    <https://metopio.com/health-atlas> to explore and import data.
    'Metopio' health atlases store open public health data. See what topics
    (or indicators) are available among specific populations, periods, and
    geographic layers. Download relevant data along with geographic 
    boundaries or point datasets. Spatial datasets are returned as 'sf' 
    objects.

Provides easy access to Brazilian public health data from multiple
    sources including VIGITEL (Surveillance of Risk Factors for Chronic Diseases
    by Telephone Survey), PNS (National Health Survey), 'PNAD' Continua (Continuous
    National Household Sample Survey), 'POF' (Household Budget Survey with food
    security and consumption data), 'Censo Demografico' (population denominators
    via 'SIDRA' API), SIM (Mortality Information System), SINASC (Live Birth
    Information System), 'SIH' (Hospital Information System),
    'SIA' (Outpatient Information System), 'SINAN' (Notifiable Diseases Surveillance),
    'CNES' (National Health Facility Registry),
    'SI-PNI' (National Immunization Program - aggregated 1994-2019 via FTP,
    individual-level 'microdata' 2020+ via 'OpenDataSUS' API),
    'SISAB' (Primary Care Health Information System - coverage indicators via
    REST API), ANS ('Agencia Nacional de Saude Suplementar' - supplementary
    health beneficiaries, consumer complaints, and financial statements),
    'ANVISA' ('Agencia Nacional de Vigilancia Sanitaria' - product registrations,
    'pharmacovigilance', 'hemovigilance', 'technovigilance', and controlled
    substance sales via 'SNGPC'),
    and other health information systems. Data is downloaded
    from the Brazilian Ministry of Health and 'IBGE' repositories. Data is returned
    in tidy format following tidyverse conventions.