Implementation of icosahedral grids in three dimensions. The spherical-triangular tessellation can be set to create grids with custom resolutions. Both the primary triangular and their inverted penta-hexagonal grids can be calculated. Additional functions are provided that allow plotting of the grids and associated data, the interaction of the grids with other raster and vector objects, and treating the grids as a graphs.

Survival analysis of interval-censored data with proportional hazards, and an explicit smooth estimate of the baseline log-hazard with P-splines.

Reproducible, programmatic retrieval of datasets from the
    Inter-university Consortium for Political and Social Research archive.

Provides functions to compute and plot Krippendorff's inter-coder 
    reliability coefficient alpha and bootstrapped uncertainty estimates 
    (Krippendorff 2004, ISBN:0761915443). The bootstrap routines are set up to
    make use of parallel threads where supported.

Implementation of Tyler, Critchley, Duembgen and Oja's (JRSS B, 2009,
            <doi:10.1111/j.1467-9868.2009.00706.x>) and Oja, Sirkia and Eriksson's
            (AJS, 2006, <https://www.ajs.or.at/index.php/ajs/article/view/vol35,%20no2%263%20-%207>) method of two different
            scatter matrices to obtain an invariant coordinate system or independent
            components, depending on the underlying assumptions.

Implementation of tandem clustering with invariant coordinate 
              selection with different scatter matrices and several choices for the 
              selection of components as described in Alfons, A., Archimbaud, A., Nordhausen, K.and Ruiz-Gazen, A. (2024) <doi:10.1016/j.ecosta.2024.03.002>.

Implements the Interval-Censored Sequence Kernel Association (ICSKAT) test for testing the association between interval-censored time-to-event outcomes and groups of single nucleotide polymorphisms (SNPs). Interval-censored time-to-event data occur when the event time is not known exactly but can be deduced to fall within a given interval. For example, some medical conditions like bone mineral density deficiency are generally only diagnosed at clinical visits. If a patient goes for clinical checkups yearly and is diagnosed at, say, age 30, then the onset of the deficiency is only known to fall between the date of their age 29 checkup and the date of the age 30 checkup. Interval-censored data include right- and left-censored data as special cases. This package also implements the interval-censored Burden test and the ICSKATO test, which is the optimal combination of the ICSKAT and Burden tests. Please see the vignette for a quickstart guide. The paper describing these methods is " Inference for Set-Based Effects in Genetic Association Studies with Interval-Censored Outcomes" by Sun R, Zhu L, Li Y, Yasui Y, & Robison L (Biometrics 2023, <doi:10.1111/biom.13636>).