Performs the Scott & Knott (1974) clustering algorithm as a
    multiple comparison method in the Analysis of Variance context, for
    both balanced and unbalanced <doi:10.1590/1984-70332017v17n1a1>
    designs. Accepts input from 'formula', 'aov', 'lm', 'aovlist', and 'lmerMod'
    objects.

The Scott-Knott Effect Size Difference (ESD) test is a mean comparison approach that leverages a hierarchical clustering to partition the set of treatment means (e.g., means of variable importance scores, means of model performance) into statistically distinct groups with non-negligible difference [Tantithamthavorn et al., (2018) <doi:10.1109/TSE.2018.2794977>].

Implements the Scout method for regression, described in "Covariance-regularized regression and classification for high-dimensional problems", by Witten and Tibshirani (2008),  Journal of the Royal Statistical Society, Series B 71(3): 615-636.

Creates a contextual menu that can be triggered with keyboard shortcuts or programmatically.
    This can replace traditional sidebars or navigation bars, thereby enhancing the 
    user experience with lighter user interfaces.

Using principal component analysis as a base model, 'SCOUTer' 
    offers a new approach to simulate outliers in a simple and precise way. 
    The user can generate new observations defining them by a pair of well-known 
    statistics: the Squared Prediction Error (SPE) and the Hotelling's T^2 (T^2) 
    statistics. Just by introducing the target values of the SPE and T^2, 'SCOUTer' 
    returns a new set of observations with the desired target properties. 
    Authors: Alba González, Abel Folch-Fortuny, Francisco Arteaga and 
    Alberto Ferrer (2020).

Implements estimators for structured covariance matrices in the
    presence of pairwise and spatial covariates.
    Metodiev, Perrot-Dockès, Ouadah, Fosdick, Robin, Latouche & Raftery (2025)
    <doi:10.48550/arXiv.2411.04520>.

Discovers synergistic gene pairs in single-cell RNA-seq and spatial transcriptomics data. Unlike conventional pairwise co-expression analyses that rely on a single correlation metric, scPairs integrates 14 complementary metrics across five orthogonal evidence layers to compute a composite synergy score with optional permutation-based significance testing. The five evidence layers span cell-level co-expression (Pearson, Spearman, biweight midcorrelation, mutual information, ratio consistency), neighbourhood-aware smoothing (KNN-smoothed correlation, neighbourhood co-expression, cluster pseudo-bulk, cross-cell-type, neighbourhood synergy), prior biological knowledge (GO/KEGG co-annotation Jaccard, pathway bridge score), trans-cellular interaction, and spatial co-variation (Lee's L, co-location quotient). This multi-scale design enables researchers to move beyond simple co-expression towards a comprehensive characterisation of cooperative gene regulation at transcriptomic and spatial resolution. For more information, see the package documentation at <https://github.com/zhaoqing-wang/scPairs>.