Utilities for reading, writing, and managing RCDF files, including encryption and decryption support. It offers a flexible interface for handling data stored in encrypted Parquet format, along with metadata extraction, key management, and secure operations using AES and RSA encryptions.

Allows the user to access functionality in the
    'CDK', a Java framework for cheminformatics. This allows the user to load
    molecules, evaluate fingerprints, calculate molecular descriptors and so on.
    In addition, the 'CDK' API allows the user to view structures in 2D.

An R interface to the Chemistry Development Kit, a Java library
    for chemoinformatics. Given the size of the library itself, this package is
    not expected to change very frequently. To make use of the CDK within R, it is
    suggested that you use the 'rcdk' package. Note that it is possible to directly
    interact with the CDK using 'rJava'. However 'rcdk' exposes functionality in a more
    idiomatic way. The CDK library itself is released as LGPL and the sources can be
    obtained from <https://github.com/cdk/cdk>.

Provides a translation layer between 'R' and 'CDO' operators. Each 
  operator is it's own function with documentation. Nested or piped functions
  will be translated into 'CDO' chains.

An implementation of a stochastic heuristic method for performing multidimensional function optimization. The method is inspired in the Cross-Entropy Method. It does not relies on derivatives, neither imposes particularly strong requirements into the function to be optimized. Additionally, it takes profit from multi-core processing to enable optimization of time-consuming functions.

Provides functions to generate censored samples of type I, II and III, from any random sample generator. It also supplies the option to create left and right censorship. Along with this, the generation of samples with interval censoring is in the  testing phase, with two options of fixed length intervals and random lengths. Additional functions generate complex inspection, delayed-entry, hybrid, progressive, covariate-dependent, frailty-dependent, and competing-risk observation structures while retaining a consistent and verifiable data object.