Identifies a bicluster, a submatrix of the data such that the features and observations within the submatrix differ from those not contained in submatrix, using a two-step method. In the first step, observations in the bicluster are  identified to maximize the sum of weighted between cluster feature differences. The method is described in Helgeson et al. (2020) <doi:10.1111/biom.13136>. 'SCBiclust' can be used to identify biclusters which differ based on feature means, feature variances, or more general differences.

Cellular population mapping (CPM) a deconvolution algorithm in which single-cell genomics is required in only one or a few samples, where in other samples of the same tissue, only bulk genomics is measured and the underlying fine resolution cellular heterogeneity is inferred.

Statistical methods for estimating and inferring the mean of functional data. The methods include simultaneous confidence bands, local polynomial fitting,  bandwidth selection by plug-in and cross-validation, goodness-of-fit tests for parametric models, equality tests for two-sample problems, and plotting functions.

Identifying spatially variable genes is critical in linking molecular cell functions 
	with tissue phenotypes. This package utilizes a granularity-based dimension-agnostic tool, 
	single-cell big-small patch (scBSP), implementing sparse matrix operation and KD tree 
	methods for distance calculation, for the identification of spatially variable genes on 
	large-scale data. The detailed description of this method is available at Wang, J. 
	and Li, J. et al. 2023 (Wang, J. and Li, J. (2023), <doi:10.1038/s41467-023-43256-5>).

Provides tools to import and export from several existing pieces of ion-channel analysis software such as 'TAC', 'QUB', 'SCAN', and 'Clampfit', implements procedures such as dwell-time correction and defining bursts with a critical time, and provides tools for analysis of bursts, such as tools for sorting and plotting.

An automatic cluster-based annotation pipeline based on evidence-based score by matching the marker genes with known cell markers in tissue-specific cell taxonomy reference database for single-cell RNA-seq data. See Shao X, et al (2020) <doi:10.1016/j.isci.2020.100882> for more details.