A collection of clinical trial designs and methods, implemented in 
    'rstan' and R, including: the Continual Reassessment Method by O'Quigley et 
    al. (1990) <doi:10.2307/2531628>; EffTox by Thall & Cook (2004) 
    <doi:10.1111/j.0006-341X.2004.00218.x>; the two-parameter logistic method of
    Neuenschwander, Branson & Sponer (2008) <doi:10.1002/sim.3230>; and the 
    Augmented Binary method by Wason & Seaman (2013) <doi:10.1002/sim.5867>; and
    more. We provide functions to aid model-fitting and analysis. 
    The 'rstan' implementations may also serve as a cookbook to anyone looking 
    to extend or embellish these models. We hope that this package encourages 
    the use of Bayesian methods in clinical trials. There is a preponderance of 
    early phase trial designs because this is where Bayesian methods are used 
    most. If there is a method you would like implemented, please get in touch.

Simulate phase II and/or phase III clinical trials. It supports various types of endpoints and adaptive strategies. Tools for carrying out graphical testing procedure and combination test under group sequential design are also provided.

Functions and Examples in Sample Size Calculation in
        Clinical Research.

Provides the "r, q, p, and d" distribution functions for the triangle distribution.  Also includes maximum likelihood estimation of parameters.

Measuring angles between points in a landscape is much easier
    than measuring distances. When the location of three points is known the
    position of the observer can be determined based solely on the angles between
    these points as seen by the observer. This task (known as triangulation)
    however requires onerous calculations - these calculations are automated by this
    package.

Compositional data consisting of three-parts can be color
  mapped with a ternary color scale. Such a scale is provided by
  the tricolore packages with options for discrete and continuous
  colors, mean-centering and scaling. See 
  Jonas Schöley (2021) "The centered ternary balance scheme. A technique
  to visualize surfaces of unbalanced three-part compositions"
  <doi:10.4054/DemRes.2021.44.19>,
  Jonas Schöley, Frans Willekens (2017) "Visualizing compositional data
  on the Lexis surface" <doi:10.4054/DemRes.2017.36.21>, and
  Ilya Kashnitsky, Jonas Schöley (2018) "Regional population structures
  at a glance" <doi:10.1016/S0140-6736(18)31194-2>.