A collection of efficient and effective tools and
	algorithms for subgroup discovery and analytics. The package
	integrates an R interface to the org.vikamine.kernel library
	of the VIKAMINE system <http://www.vikamine.org> implementing
	subgroup discovery, pattern mining and analytics in Java.

Produces tables with the level of replication (number of replicates) and the
    experimental uncoded values of the quantitative factors to be used for rotatable Central
    Composite Design (CCD) experimentation and a 2-D contour plot of the corresponding
    variance of the predicted response according to
    Mead et al. (2012) <doi:10.1017/CBO9781139020879> design_ccd(), and analyzes
    CCD data with response surface methodology ccd_analysis(). A rotatable CCD
    provides values of the variance of the predicted response that are concentrically
    distributed around the average treatment combination used in the experimentation, which
    with uniform precision (implied by the use of several replicates at the average
    treatment combination) improves greatly the search and finding of an optimum response.
    These properties of a rotatable CCD represent undeniable advantages over the classical
    factorial design, as discussed by Panneton et al. (1999) <doi:10.13031/2013.13267> and
    Mead et al. (2012) <doi:10.1017/CBO9781139020879.018> among others.

Provides functions to estimate the proportion of treatment effect on the primary outcome that is explained by the treatment effect on the surrogate marker.

Random generation of survival data from a wide range of regression models, including accelerated failure time (AFT), proportional hazards (PH), proportional odds (PO), accelerated hazard (AH), Yang and Prentice (YP), and extended hazard (EH) models. The package 'rsurv' also stands out by its ability to generate survival data from an unlimited number of baseline distributions provided that an implementation of the quantile function of the chosen baseline distribution is available in R. Another nice feature of the package 'rsurv' lies in the fact that linear predictors are specified via a formula-based approach, facilitating the inclusion of categorical variables and interaction terms. The functions implemented in the package 'rsurv' can also be employed to simulate survival data with more complex structures, such as survival data with different types of censoring mechanisms, survival data with cure fraction, survival data with random effects (frailties), multivariate survival data, and competing risks survival data. Details about the R package 'rsurv' can be found in Demarqui (2024) <doi:10.48550/arXiv.2406.01750>.