An extension of the Fisher Scoring Algorithm to combine PLS regression with GLM 
    estimation in the multivariate context. Covariates can also be grouped in themes.

Traditional methods for analyzing single cell RNA-seq datasets focus solely on gene expression, but this package introduces a novel approach that goes beyond this limitation. Using Gene Ontology terms as features, the package allows for the functional profile of cell populations, and comparison within and between datasets from the same or different species. Our approach enables the discovery of previously unrecognized functional similarities and differences between cell types and has demonstrated success in identifying cell types' functional correspondence even between evolutionarily distant species.

Fast and regularized version of GWR for large dataset, detailed in Murakami, Tsutsumida, Yoshida, Nakaya, and Lu (2019) <arXiv:1905.00266>.

Provides methods to detect structural changes in time series or random fields (spatial data). Focus is on the detection of abrupt changes or trends in independent data, but the package also provides a function to de-correlate data with dependence. The functions are based on the test suggested in Schmidt (2024) <DOI:10.3150/23-BEJ1686> and the work in Görz and Fried (2025) <DOI:10.48550/arXiv.2512.11599>.

Offers classes and functions to contact web servers while enforcing scheduling rules required by the sites. The URL class makes it easy to construct a URL by providing parameters as a vector. The Request class allows to describes SOAP (Simple Object Access Protocol) or standard requests: URL, method (POST or GET), header, body. The Scheduler class controls the request frequency for each server address by mean of rules (Rule class). The RequestResult class permits to get the request status to handle error cases and the content.

Provides a compact schema domain-specific language for inferring,
    editing, and validating R data structures with 'checkmate' checks.
    Schemas can be serialized to and restored from JSON for storage and
    review. A generated standalone bundle supports vendoring the schema
    tools into other R packages.