Cauchy Weighted Joint Test for Pharmacogenetics Analysis R package cwot version 0.1.0 A flexible and robust joint test of the single nucleotide polymorphism (SNP) main effect and genotype-by-treatment interaction effect for continuous and binary endpoints. Two analytic procedures, Cauchy weighted joint test (CWOT) and adaptively weighted joint test (AWOT), are proposed to accurately calculate the joint test p-value. The proposed methods are evaluated through extensive simulations under various scenarios. The results show that the proposed AWOT and CWOT control type I error well and outperform existing methods in detecting the most interesting signal patterns in pharmacogenetics (PGx) association studies. For reference, see Hong Zhang, Devan Mehrotra and Judong Shen (2022) <doi:10.13140/RG.2.2.28323.53280>. Software Imports: stats, SPAtest, mvtnorm Hong Zhang <hzhang@wpi.edu> Comprehensive R Archive Network (CRAN) Hong Zhang [aut, cre] (ORCID: <https://orcid.org/0000-0002-8869-8671>) GPL-2 2022-09-23 application/tgz https://CRAN.R-project.org/package=cwot doi:10.32614/CRAN.package.cwot