Mixed Effects Cox Models R package coxme version 2.2-22 CRAN Task View: Agriculture (https://CRAN.R-project.org/view=Agriculture) CRAN Task View: MixedModels (https://CRAN.R-project.org/view=MixedModels) CRAN Task View: Survival (https://CRAN.R-project.org/view=Survival) Fit Cox proportional hazards models containing both fixed and random effects. The random effects can have a general form, of which familial interactions (a "kinship" matrix) is a particular special case. Note that the simplest case of a mixed effects Cox model, i.e. a single random per-group intercept, is also called a "frailty" model. The approach is based on Ripatti and Palmgren, Biometrics 2002. Software Depends: survival (>= 2.36.14), methods, bdsmatrix(>= 1.3), R(>= 2.10) Imports: nlme, Matrix (>= 1.0) LinkingTo: bdsmatrix Suggests: mvtnorm, kinship2 Terry M. Therneau <therneau.terry@mayo.edu> Comprehensive R Archive Network (CRAN) Terry M. Therneau [aut, cre] LGPL-2 2024-08-23 application/tgz https://CRAN.R-project.org/package=coxme doi:10.32614/CRAN.package.coxme