Using Multiple Continuous Biomarkers for Patient Enrichment in Two-Stage Clinical Designs R package cobenrich version 1.0.1 Enrichment strategies play a critical role in modern clinical trial design, especially as precision medicine advances the focus on patient-specific efficacy. Recent developments in enrichment design have introduced biomarker randomness and accounted for the correlation structure between treatment effect and biomarker, resulting in a two-stage threshold enrichment design. We propose novel two-stage enrichment designs capable of handling two or more continuous biomarkers. See Zhang, F. and Gou, J. (2025). Using multiple biomarkers for patient enrichment in two-stage clinical designs. Technical Report. Software Depends: R (>= 4.2.0) Imports: tmvtnorm (>= 1.2), stats (>= 4.0.0) Jiangtao Gou <gouRpackage@gmail.com> Comprehensive R Archive Network (CRAN) Jiangtao Gou [aut, cre], Fengqing (Zoe) Zhang [aut] GPL-3 2025-04-15 application/tgz https://CRAN.R-project.org/package=cobenrich doi:10.32614/CRAN.package.cobenrich