Spatially-Aware Cell Clustering Algorithm with Cluster Significant Assessment R package coFAST version 0.3.0 A spatially-aware cell clustering algorithm is provided with cluster significance assessment. It comprises four key modules: spatially-aware cell-gene co-embedding, cell clustering, signature gene identification, and cluster significant assessment. More details can be referred to Peng Xie, et al. (2025) <doi:10.1016/j.cell.2025.05.035>. Software Depends: R (>= 4.0.0), Imports: Rcpp (>= 1.0.10), furrr, purrr, future, ggplot2, irlba, DR.SC, ProFAST, Matrix, ade4, progress, pbapply, dplyr, Seurat, stats, utils LinkingTo: Rcpp, RcppArmadillo Suggests: knitr, rmarkdown, scater, PRECAST, ggrepel, RANN, grDevices Wei Liu <liuweideng@gmail.com> Comprehensive R Archive Network (CRAN) Wei Liu [aut, cre], Xiao Zhang [aut], Yi Yang [aut], Peng Xie [aut], Chengqi Lin [aut], Jin Liu [aut] GPL-3 2026-06-04 application/tgz https://CRAN.R-project.org/package=coFAST doi:10.32614/CRAN.package.coFAST