<?xml version="1.0" encoding="UTF-8"?>
<oai_dc:dc xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:title>Component, Dose, and Time Network Meta-Analysis with
Dose-Dependent Interactions</dc:title>
  <dc:title>R package cdtmbnma version 0.2.1</dc:title>
  <dc:description>Bayesian component model-based network meta-analysis for treatment
    combinations with explicit component dose-response and dose-dependent
    interaction surfaces. The main interface fits single-timepoint arm-level
    networks with continuous or binary outcomes, any number of components,
    additive, bilinear, or saturating pairwise interactions, study-level random
    effects, and prediction at unobserved dose combinations. A stage-one
    longitudinal interface fits a two-component exponential time-course model
    with a bilinear interaction on the asymptote. Estimation uses 'Stan' through
    'cmdstanr' or 'rstan'. Methods are described in Welton et al. (2009)
    &lt;doi:10.1093/aje/kwp014&gt;, Mawdsley et al. (2016) &lt;doi:10.1002/psp4.12091&gt;,
    Wicha et al. (2017) &lt;doi:10.1038/s41467-017-01929-y&gt;, and Pedder et al.
    (2019) &lt;doi:10.1002/jrsm.1351&gt;.</dc:description>
  <dc:type>Software</dc:type>
  <dc:relation>Depends: R (&gt;= 4.1.0)</dc:relation>
  <dc:relation>Imports: posterior, stats, graphics, grDevices, utils</dc:relation>
  <dc:relation>Suggests: cmdstanr, rstan, testthat (&gt;= 3.0.0), knitr, rmarkdown, loo</dc:relation>
  <dc:creator>Tyler Pitre &lt;pitretmed@gmail.com&gt;</dc:creator>
  <dc:publisher>Comprehensive R Archive Network (CRAN)</dc:publisher>
  <dc:contributor>Tyler Pitre [aut, cre]</dc:contributor>
  <dc:rights>MIT + file LICENSE (https://CRAN.R-project.org/package=cdtmbnma/LICENSE)</dc:rights>
  <dc:date>2026-07-22</dc:date>
  <dc:format>application/tgz</dc:format>
  <dc:identifier>https://CRAN.R-project.org/package=cdtmbnma</dc:identifier>
  <dc:identifier>doi:10.32614/CRAN.package.cdtmbnma</dc:identifier>
</oai_dc:dc>
