Methods for Detecting Safety Signals in Clinical Trials Using Body-Systems (System Organ Classes) R package c212 version 1.0.1 Provides a self-contained set of methods to aid clinical trial safety investigators, statisticians and researchers, in the early detection of adverse events using groupings by body-system or system organ class. This work was supported by the Engineering and Physical Sciences Research Council (UK) (EPSRC) [award reference 1521741] and Frontier Science (Scotland) Ltd. The package title c212 is in reference to the original Engineering and Physical Sciences Research Council (UK) funded project which was named CASE 2/12. Software Depends: coda (>= 0.19) Raymond Carragher <rcarragh@gmail.com> Comprehensive R Archive Network (CRAN) Raymond Carragher [aut, cre] (ORCID: <https://orcid.org/0000-0002-0120-625X>) GPL-3 2024-11-05 application/tgz https://CRAN.R-project.org/package=c212 doi:10.32614/CRAN.package.c212