<?xml version="1.0" encoding="UTF-8"?>
<oai_dc:dc xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:title>A Family of Beta Mixture Models for Clustering Beta-Valued DNA
Methylation Data</dc:title>
  <dc:title>R package betaclust version 1.0.5</dc:title>
  <dc:description>A family of novel beta mixture models (BMMs) has been developed by Majumdar et al. (2022) &lt;doi:10.48550/arXiv.2211.01938&gt; to appositely model the beta-valued cytosine-guanine dinucleotide (CpG) sites, to objectively identify methylation state thresholds and to identify the differentially methylated CpG (DMC) sites using a model-based clustering approach. The family of beta mixture models employs different parameter constraints applicable to different study settings. The EM algorithm is used for parameter estimation, with a novel approximation during the M-step providing tractability and ensuring computational feasibility.</dc:description>
  <dc:type>Software</dc:type>
  <dc:relation>Depends: R (&gt;= 3.5.0)</dc:relation>
  <dc:relation>Imports: foreach, doParallel, stats, utils, ggplot2, plotly, scales,
pROC</dc:relation>
  <dc:relation>Suggests: rmarkdown, knitr</dc:relation>
  <dc:creator>Koyel Majumdar &lt;koyelmajumdar.phdresearch@gmail.com&gt;</dc:creator>
  <dc:publisher>Comprehensive R Archive Network (CRAN)</dc:publisher>
  <dc:contributor>Koyel Majumdar [aut, cre] (ORCID:
    &lt;https://orcid.org/0000-0003-4692-9002&gt;),
  Romina Silva [aut],
  Antoinette Sabrina Perry [aut],
  Ronald William Watson [aut],
  Andrea Rau [aut] (ORCID: &lt;https://orcid.org/0000-0001-6469-488X&gt;),
  Florence Jaffrezic [aut],
  Thomas Brendan Murphy [aut] (ORCID:
    &lt;https://orcid.org/0000-0002-5668-7046&gt;),
  Isobel Claire Gormley [aut] (ORCID:
    &lt;https://orcid.org/0000-0001-7713-681X&gt;)</dc:contributor>
  <dc:rights>GPL-3</dc:rights>
  <dc:date>2025-09-19</dc:date>
  <dc:format>application/tgz</dc:format>
  <dc:identifier>https://CRAN.R-project.org/package=betaclust</dc:identifier>
  <dc:identifier>doi:10.32614/CRAN.package.betaclust</dc:identifier>
</oai_dc:dc>
