Design and Analysis of Locally or Globally Efficient Adaptive Designs R package adpss version 0.1.2 CRAN Task View: ClinicalTrials (https://CRAN.R-project.org/view=ClinicalTrials) Provides the functions for planning and conducting a clinical trial with adaptive sample size determination. Maximal statistical efficiency will be exploited even when dramatic or multiple adaptations are made. Such a trial consists of adaptive determination of sample size at an interim analysis and implementation of frequentist statistical test at the interim and final analysis with a prefixed significance level. The required assumptions for the stage-wise test statistics are independent and stationary increments and normality. Predetermination of adaptation rule is not required. Software Depends: R (>= 3.5.0) Imports: Rcpp (>= 0.12.17) LinkingTo: Rcpp (>= 0.12.17) Suggests: knitr, rmarkdown Kosuke Kashiwabara <kashiwabara-tky@umin.ac.jp> Comprehensive R Archive Network (CRAN) Kosuke Kashiwabara [aut, cre] GPL (>= 2) 2022-12-09 application/tgz https://CRAN.R-project.org/package=adpss doi:10.32614/CRAN.package.adpss