Adaptive Optimal Two-Stage Designs R package adoptr version 1.1.2 CRAN Task View: ClinicalTrials (https://CRAN.R-project.org/view=ClinicalTrials) Optimize one or two-arm, two-stage designs for clinical trials with respect to several implemented objective criteria or custom objectives. Optimization under uncertainty and conditional (given stage-one outcome) constraints are supported. See Pilz et al. (2019) <doi:10.1002/sim.8291> and Kunzmann et al. (2021) <doi:10.18637/jss.v098.i09> for details. Software Imports: nloptr, methods, glue Suggests: knitr, rmarkdown, testthat, covr, rpact, vdiffr, pwr, dplyr, ggplot2, tidyr, gridExtra, bookdown Maximilian Pilz <maximilian.pilz@th-nuernberg.de> Comprehensive R Archive Network (CRAN) Kevin Kunzmann [aut, cph] (ORCID: <https://orcid.org/0000-0002-1140-7143>), Maximilian Pilz [aut, cre] (ORCID: <https://orcid.org/0000-0002-9685-1613>), Jan Meis [aut] (ORCID: <https://orcid.org/0000-0001-5407-7220>), Nico Bruder [aut] (ORCID: <https://orcid.org/0009-0004-9522-2075>) MIT + file LICENSE (https://CRAN.R-project.org/package=adoptr/LICENSE) 2026-05-03 application/tgz https://CRAN.R-project.org/package=adoptr doi:10.32614/CRAN.package.adoptr