Adaptive Bioequivalence Design for In-Vitro Permeation Tests R package adaptIVPT version 1.1.0 CRAN Task View: ClinicalTrials (https://CRAN.R-project.org/view=ClinicalTrials) Contains functions carrying out adaptive procedures using mixed scaling approach to establish bioequivalence for in-vitro permeation test (IVPT) data. Currently, the package provides procedures based on parallel replicate design and balanced data, according to the U.S. Food and Drug Administration's "Draft Guidance on Acyclovir" <https://www.accessdata.fda.gov/drugsatfda_docs/psg/Acyclovir_topical%20cream_RLD%2021478_RV12-16.pdf>. Potvin et al. (2008) <doi:10.1002/pst.294> provides the basis for our adaptive design (see Method B). For a comprehensive overview of the method, refer to Lim et al. (2023) <doi:10.1002/pst.2333>. This package reflects the views of the authors and should not be construed to represent the views or policies of the U.S. Food and Drug Administration. Software Depends: R (>= 3.4) Imports: Rcpp, rgl LinkingTo: Rcpp, RcppArmadillo, RcppProgress Suggests: knitr, rmarkdown Daeyoung Lim <Daeyoung.Lim@fda.hhs.gov> Comprehensive R Archive Network (CRAN) Daeyoung Lim [aut, cre], Elena Rantou [ctb], Jessica Kim [ctb], Sungwoo Choi [ctb], Nam Hee Choi [ctb], Stella Grosser [ctb] GPL (>= 3) 2024-01-26 application/tgz https://CRAN.R-project.org/package=adaptIVPT doi:10.32614/CRAN.package.adaptIVPT