Dose-Finding Methods for Non-Binary Outcomes R package UnifiedDoseFinding version 0.1.10 CRAN Task View: ClinicalTrials (https://CRAN.R-project.org/view=ClinicalTrials) CRAN Task View: Pharmacokinetics (https://CRAN.R-project.org/view=Pharmacokinetics) In many phase I trials, the design goal is to find the dose associated with a certain target toxicity rate. In some trials, the goal can be to find the dose with a certain weighted sum of rates of various toxicity grades. For others, the goal is to find the dose with a certain mean value of a continuous response. This package provides the setup and calculations needed to run a dose-finding trial with non-binary endpoints and performs simulations to assess design’s operating characteristics under various scenarios. Three dose finding designs are included in this package: unified phase I design (Ivanova et al. (2009) <doi:10.1111/j.1541-0420.2008.01045.x>), Quasi-CRM/Robust-Quasi-CRM (Yuan et al. (2007) <doi:10.1111/j.1541-0420.2006.00666.x>, Pan et al. (2014) <doi:10.1371/journal.pone.0098147>) and generalized BOIN design (Mu et al. (2018) <doi:10.1111/rssc.12263>). The toxicity endpoints can be handled with these functions including equivalent toxicity score (ETS), total toxicity burden (TTB), general continuous toxicity endpoints, with incorporating ordinal grade toxicity information into dose-finding procedure. These functions allow customization of design characteristics to vary sample size, cohort sizes, target dose-limiting toxicity (DLT) rates, discrete or continuous toxicity score, and incorporate safety and/or stopping rules. Software Chia-Wei Hsu <Chia-Wei.Hsu@stjude.org> Comprehensive R Archive Network (CRAN) Chia-Wei Hsu, Haitao Pan, Rongji Mu GPL-2 2022-10-15 application/tgz https://CRAN.R-project.org/package=UnifiedDoseFinding doi:10.32614/CRAN.package.UnifiedDoseFinding