<?xml version="1.0" encoding="UTF-8"?>
<oai_dc:dc xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:title>Multiple Imputation Method in Survival Analysis</dc:title>
  <dc:title>R package SurvMI version 0.1.0</dc:title>
  <dc:description>In clinical trials, endpoints are sometimes evaluated with uncertainty. Adjudication is commonly adopted to ensure the study integrity. We propose to use multiple imputation (MI) introduced by Robin (1987) &lt;doi:10.1002/9780470316696&gt; to incorporate these uncertainties if reasonable event probabilities were provided. The method has been applied to Cox Proportional Hazard (PH) model, Kaplan-Meier (KM) estimation and Log-rank test in this package. Moreover, weighted estimations discussed in Cook (2004) &lt;doi:10.1016/S0197-2456(00)00053-2&gt; were also implemented with weights calculated from event probabilities. In conclusion, this package can handle time-to-event analysis if events presented with uncertainty by different methods. </dc:description>
  <dc:type>Software</dc:type>
  <dc:relation>Depends: R(&gt;= 3.4.0)</dc:relation>
  <dc:relation>Imports: survival (&gt;= 3.1.11), zoo, stats, graphics, base</dc:relation>
  <dc:creator>Yiming Chen &lt;yimingc1208@gmail.com&gt;</dc:creator>
  <dc:publisher>Comprehensive R Archive Network (CRAN)</dc:publisher>
  <dc:contributor>Yiming Chen [aut, cre],
  John Lawrence [ctb]</dc:contributor>
  <dc:rights>GPL-2</dc:rights>
  <dc:date>2020-07-13</dc:date>
  <dc:format>application/tgz</dc:format>
  <dc:identifier>https://CRAN.R-project.org/package=SurvMI</dc:identifier>
  <dc:identifier>doi:10.32614/CRAN.package.SurvMI</dc:identifier>
</oai_dc:dc>
