Spatially Aware Cell-Cell Interaction Analysis R package SpaCCI version 1.0.5 Provides tools for analyzing spatial cell-cell interactions based on ligand-receptor pairs, including functions for local, regional, and global analysis using spatial transcriptomics data. Integrates with databases like 'CellChat' <https://github.com/jinworks/CellChat>, 'CellPhoneDB' <https://www.cellphonedb.org/>, 'Cellinker' <https://www.rna-society.org/cellinker/>, 'ICELLNET' <https://github.com/soumelis-lab/ICELLNET>, and 'ConnectomeDB' <https://humanconnectome.org/software/connectomedb/> to identify ligand-receptor pairs, visualize interactions through heatmaps, chord diagrams, and infer interactions on different spatial scales. Software Depends: R (>= 3.5.0) Imports: Rcpp (>= 1.0.13), Seurat (>= 4.0.0), nnls, ggrepel, pheatmap, circlize (>= 0.4.12), Matrix, dplyr, patchwork, grDevices, reshape2, graphics, ggplot2, FNN, rlang LinkingTo: Rcpp, RcppArmadillo Li-Ting Ku <lku@mdanderson.org> Comprehensive R Archive Network (CRAN) Li-Ting Ku [aut, cre] GPL (>= 2) 2026-02-27 application/tgz https://CRAN.R-project.org/package=SpaCCI doi:10.32614/CRAN.package.SpaCCI