Building, Fitting and Evaluating PK/PD Modeles R package SimuRg version 0.2.0 Provides a unified workflow for building, fitting using external engines, and evaluating ordinary differential equation (ODE)-based pharmacokinetic/pharmacodynamic (PK/PD) models. Supports generation of estimation scenarios and control files for external engines (e.g., 'Monolix'), simulation of models using 'rxode2', and creation of goodness-of-fit diagnostics. Includes tools for covariate modeling, virtual population design, and local and global sensitivity analyses. Software Depends: R (>= 3.5) Imports: cluster, dplyr, fastDummies, forcats, ggplot2, jsonlite, MASS, philentropy, purrr, readr, recipes, rlang, rxode2, scales, stringr, synthpop, sys, tibble, tidyr, uwot, zoo, lhs, sensitivity, ppcor, withr Suggests: GGally, testthat (>= 3.0.0) Anna Mikhailova <anna.mikhailova@msdecisions.tech> Comprehensive R Archive Network (CRAN) Victor Sokolov [cph, aut], Anna Mikhailova [cre], Yaroslav Ugolkov [aut], Anatoly Pokladyuk [aut], Alina Melnikova [aut], Victoria Kulesh [aut] MIT + file LICENSE (https://CRAN.R-project.org/package=SimuRg/LICENSE) 2026-05-19 application/tgz https://CRAN.R-project.org/package=SimuRg doi:10.32614/CRAN.package.SimuRg