<?xml version="1.0" encoding="UTF-8"?>
<oai_dc:dc xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:title>Modeling and Assessing Similarity of Drug Dissolutions Profiles</dc:title>
  <dc:title>R package SimDissolution version 0.1.0</dc:title>
  <dc:description>Implementation of a model-based bootstrap approach for testing whether two formulations are similar. The package provides a function for fitting a pharmacokinetic model to time-concentration data and comparing the results for all five candidate models regarding the Residual Sum of Squares (RSS). The candidate set contains a First order, Hixson-Crowell, Higuchi, Weibull and a logistic model. The assessment of similarity implemented in this package is performed regarding the maximum deviation of the profiles. See Moellenhoff et al. (2018) &lt;doi:10.1002/sim.7689&gt; for details.</dc:description>
  <dc:type>Software</dc:type>
  <dc:relation>Depends: dplyr, alabama, mvtnorm, graphics</dc:relation>
  <dc:creator>Kathrin Moellenhoff &lt;kathrin.moellenhoff@rub.de&gt;</dc:creator>
  <dc:publisher>Comprehensive R Archive Network (CRAN)</dc:publisher>
  <dc:contributor>Kathrin Moellenhoff</dc:contributor>
  <dc:rights>GPL (&gt;= 2)</dc:rights>
  <dc:date>2019-09-27</dc:date>
  <dc:format>application/tgz</dc:format>
  <dc:identifier>https://CRAN.R-project.org/package=SimDissolution</dc:identifier>
  <dc:identifier>doi:10.32614/CRAN.package.SimDissolution</dc:identifier>
</oai_dc:dc>