Selected Events Linked by Evolutionary Conditions in Cancer R package SelectSim version 0.1.6 Implements the 'SelectSim' methodology for identifying patterns of co-occurrence and mutual exclusivity between functional genomic alterations in cancer cohorts. The package processes mutation annotation data, constructs alteration matrices, estimates expected alteration-pair frequencies, and quantifies deviations associated with selective interactions. The methodology is described in Iyer et al. (2026) <doi:10.1038/s41588-026-02661-4>. Software Depends: R (>= 3.5) Imports: doParallel, doRNG, dplyr, foreach, ggplot2, ggpubr, ggridges, Matrix, parallel, Rcpp, Rfast, stats LinkingTo: Rcpp, RcppArmadillo Suggests: knitr, rmarkdown, testthat (>= 3.0.0), tictoc Arvind Iyer <ayalurarvind@gmail.com> Comprehensive R Archive Network (CRAN) Arvind Iyer [aut, cre, cph] (ORCID: <https://orcid.org/0000-0002-8247-700X>), Marco Mina [aut], Miljan Petrovic [aut, cph], Giovanni Ciriello [aut, cph] (ORCID: <https://orcid.org/0000-0003-2021-8683>) MIT + file LICENSE (https://CRAN.R-project.org/package=SelectSim/LICENSE) 2026-07-21 application/tgz https://CRAN.R-project.org/package=SelectSim doi:10.32614/CRAN.package.SelectSim en-US