<?xml version="1.0" encoding="UTF-8"?>
<oai_dc:dc xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:title>A Spatial Model of Intra-Tumor Heterogeneity</dc:title>
  <dc:title>R package SITH version 1.1.0</dc:title>
  <dc:description>Implements a three-dimensional stochastic model of cancer growth and mutation similar to the one described in Waclaw et al. (2015) &lt;doi:10.1038/nature14971&gt;. Allows for interactive 3D visualizations of the simulated tumor. Provides a comprehensive summary of the spatial distribution of mutants within the tumor. Contains functions which create synthetic sequencing datasets from the generated tumor. </dc:description>
  <dc:type>Software</dc:type>
  <dc:relation>Depends: R (&gt;= 3.6.0)</dc:relation>
  <dc:relation>Imports: Rcpp (&gt;= 1.0.4), scatterplot3d, stats, graphics, grDevices</dc:relation>
  <dc:relation>LinkingTo: Rcpp</dc:relation>
  <dc:relation>Suggests: rgl, igraph, knitr, rmarkdown, testthat</dc:relation>
  <dc:creator>Phillip B. Nicol &lt;philnicol740@gmail.com&gt;</dc:creator>
  <dc:publisher>Comprehensive R Archive Network (CRAN)</dc:publisher>
  <dc:contributor>Phillip B. Nicol</dc:contributor>
  <dc:rights>GPL (&gt;= 2)</dc:rights>
  <dc:date>2021-01-05</dc:date>
  <dc:format>application/tgz</dc:format>
  <dc:identifier>https://CRAN.R-project.org/package=SITH</dc:identifier>
  <dc:identifier>doi:10.32614/CRAN.package.SITH</dc:identifier>
</oai_dc:dc>