Signature Analyzer for Targeted Sequencing R package SATS version 1.0.10 SATS stands for Signature Analyzer for Targeted Sequencing and performs mutational signature analysis for targeted sequenced tumors. Unlike the canonical analysis of mutational signatures, SATS factorizes the mutation counts matrix into a panel context matrix (measuring the size of the targeted sequenced genome for each tumor in the unit of million base pairs (Mb)), a signature profile matrix, and a signature activity matrix. SATS also calculates the expected number of mutations attributed by a signature, namely signature burden, for each targeted sequenced tumor. For more details see Lee et al. (2024) <doi:10.1101/2023.05.18.23290188>. Software Depends: R (>= 4.1.0) Imports: stats, glmnet, GenomicRanges, IRanges, Biostrings, dplyr, Suggests: testthat, BSgenome.Hsapiens.UCSC.hg19, BSgenome.Hsapiens.UCSC.hg38 Bill Wheeler <wheelerb@imsweb.com> Comprehensive R Archive Network (CRAN) DongHyuk Lee [aut], Bin Zhu [aut], Bill Wheeler [cre] GPL-2 2026-07-09 application/tgz https://CRAN.R-project.org/package=SATS doi:10.32614/CRAN.package.SATS