Identify Mutually Exclusive Mutations R package Rediscover version 0.3.3 CRAN Task View: Omics (https://CRAN.R-project.org/view=Omics) An optimized method for identifying mutually exclusive genomic events. Its main contribution is a statistical analysis based on the Poisson-Binomial distribution that takes into account that some samples are more mutated than others. See [Canisius, Sander, John WM Martens, and Lodewyk FA Wessels. (2016) "A novel independence test for somatic alterations in cancer shows that biology drives mutual exclusivity but chance explains most co-occurrence." Genome biology 17.1 : 1-17. <doi:10.1186/s13059-016-1114-x>]. The mutations matrices are sparse matrices. The method developed takes advantage of the advantages of this type of matrix to save time and computing resources. Software Depends: R (>= 4.0), Matrix, PoissonBinomial, ShiftConvolvePoibin, utils, matrixStats Imports: maftools, data.table, parallel, RColorBrewer, methods Suggests: knitr, rmarkdown, RUnit, BiocStyle, dplyr, kableExtra, magick, qvalue, testthat (>= 3.0.0) Juan A. Ferrer-Bonsoms <jafhernandez@tecnun.es> Comprehensive R Archive Network (CRAN) Juan A. Ferrer-Bonsoms [aut, cre], Laura Jareno [aut], Angel Rubio [aut] Artistic-2.0 2025-12-19 application/tgz https://CRAN.R-project.org/package=Rediscover doi:10.32614/CRAN.package.Rediscover