<?xml version="1.0" encoding="UTF-8"?>
<oai_dc:dc xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:title>Rank Normal Transformation Omnibus Test</dc:title>
  <dc:title>R package RNOmni version 1.0.1.2</dc:title>
  <dc:description>Inverse normal transformation (INT) based genetic association testing. These tests are recommend for continuous traits with non-normally distributed residuals. INT-based tests robustly control the type I error in settings where standard linear regression does not, as when the residual distribution exhibits excess skew or kurtosis. Moreover, INT-based tests outperform standard linear regression in terms of power. These tests may be classified into two types. In direct INT (D-INT), the phenotype is itself transformed. In indirect INT (I-INT), phenotypic residuals are transformed. The omnibus test (O-INT) adaptively combines D-INT and I-INT into a single robust and statistically powerful approach. See McCaw ZR, Lane JM, Saxena R, Redline S, Lin X. "Operating characteristics of the rank-based inverse normal transformation for quantitative trait analysis in genome-wide association studies" &lt;doi:10.1111/biom.13214&gt;.</dc:description>
  <dc:type>Software</dc:type>
  <dc:relation>Depends: R (&gt;= 3.2.2)</dc:relation>
  <dc:relation>Imports: plyr, Rcpp, stats</dc:relation>
  <dc:relation>LinkingTo: Rcpp, RcppArmadillo</dc:relation>
  <dc:relation>Suggests: testthat (&gt;= 3.0.0), withr, R.rsp</dc:relation>
  <dc:creator>Zachary McCaw &lt;zmccaw@alumni.harvard.edu&gt;</dc:creator>
  <dc:publisher>Comprehensive R Archive Network (CRAN)</dc:publisher>
  <dc:contributor>Zachary McCaw [aut, cre] (ORCID:
    &lt;https://orcid.org/0000-0002-2006-9828&gt;)</dc:contributor>
  <dc:rights>GPL-3</dc:rights>
  <dc:date>2023-09-11</dc:date>
  <dc:format>application/tgz</dc:format>
  <dc:identifier>https://CRAN.R-project.org/package=RNOmni</dc:identifier>
  <dc:identifier>doi:10.32614/CRAN.package.RNOmni</dc:identifier>
</oai_dc:dc>
