tcpl: ToxCast Data Analysis Pipeline

The ToxCast Data Analysis Pipeline ('tcpl') is an R package that manages, curve-fits, plots, and stores ToxCast data to populate its linked MySQL database, 'invitrodb'. The package was developed for the chemical screening data curated by the US EPA's Toxicity Forecaster (ToxCast) program, but 'tcpl' can be used to support diverse chemical screening efforts.

Version: 3.3.0
Depends: R (≥ 4.1.0)
Imports: data.table (≥ 1.15.0), DBI, RMariaDB, numDeriv, RColorBrewer, utils, stats, methods, graphics, grDevices, sqldf, dplyr, tidyr, plotly, tcplfit2, ggplot2, gridExtra, stringr, rlang, ctxR (≥ 1.1.0), viridis, gt
Suggests: roxygen2, knitr, prettydoc, rmarkdown, htmlTable, testthat (≥ 3.0.0), reshape2, kableExtra, colorspace, magrittr, vdiffr, httptest, rmdformats, gtable
Published: 2025-05-05
DOI: 10.32614/CRAN.package.tcpl
Author: Dayne L Filer [aut], Jason Brown ORCID iD [ctb], Madison Feshuk ORCID iD [cre], Carter Thunes [ctb], Sarah E Davidson-Fritz ORCID iD [ctb], Kelly Carstens ORCID iD [ctb], Elizabeth Gilson [ctb], Lindsay Knupp [ctb], Lori Kolaczkowski [ctb], Ashley Ko [ctb], Zhihui Zhao [ctb], Kurt Dunham [ctb], Todd Zurlinden ORCID iD [ctb], Parth Kothiya [ctb], Woodrow R Setzer [ctb], Matthew T Martin [ctb, ths], Richard S Judson ORCID iD [ctb, ths], Katie Paul Friedman ORCID iD [ctb]
Maintainer: Madison Feshuk <feshuk.madison at epa.gov>
BugReports: https://github.com/USEPA/CompTox-ToxCast-tcpl/issues
License: MIT + file LICENSE
URL: https://github.com/USEPA/CompTox-ToxCast-tcpl, https://www.epa.gov/comptox-tools/toxicity-forecasting-toxcast
NeedsCompilation: no
Materials: README NEWS
CRAN checks: tcpl results

Documentation:

Reference manual: tcpl.pdf
Vignettes: 1. Introduction to tcpl and invitrodb (source, R code)

Downloads:

Package source: tcpl_3.3.0.tar.gz
Windows binaries: r-devel: tcpl_3.3.0.zip, r-release: tcpl_3.2.1.zip, r-oldrel: tcpl_3.2.1.zip
macOS binaries: r-release (arm64): tcpl_3.3.0.tgz, r-oldrel (arm64): tcpl_3.3.0.tgz, r-release (x86_64): tcpl_3.3.0.tgz, r-oldrel (x86_64): tcpl_3.3.0.tgz
Old sources: tcpl archive

Reverse dependencies:

Reverse suggests: Rcurvep, tcplfit2, toxEval

Linking:

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