Package: DRviaSPCN
Type: Package
Title: Drug Repurposing in Cancer via a Subpathway Crosstalk Network
Version: 0.1.5
Maintainer: Junwei Han <hanjunwei1981@163.com>
Authors@R: c(person(given = "Junwei", family = "Han", email = "hanjunwei1981@163.com", role  = c("aut", "cre", "cph")),
             person(given = "Jiashuo", family = "Wu", role  = "aut"))
Description: A systematic biology tool was developed to repurpose drugs via a subpathway crosstalk network. The operation modes include 1) calculating centrality scores of SPs in the context of gene expression data to reflect the influence of SP crosstalk, 2) evaluating drug-disease reverse association based on disease- and drug-induced SPs weighted by the SP crosstalk, 3) identifying cancer candidate drugs through perturbation analysis. There are also several functions used to visualize the results.
License: GPL (>= 2)
Encoding: UTF-8
LazyData: true
RoxygenNote: 7.3.2
Imports: GSVA, clusterProfiler, graphics, igraph, pheatmap, stats
Depends: R (>= 3.6)
Suggests: rmarkdown, knitr, DT
VignetteBuilder: knitr
NeedsCompilation: no
Packaged: 2024-12-17 01:21:45 UTC; Nek
Author: Junwei Han [aut, cre, cph],
  Jiashuo Wu [aut]
Repository: CRAN
Date/Publication: 2025-01-09 11:20:06 UTC
Built: R 4.4.3; ; 2026-02-23 14:22:23 UTC; windows
