******************************************************************
*      oral1_project.mlxtran
*      October 26, 2016 at 17:04:47
*      Monolix version: 4.4.0
******************************************************************

Estimation of the population parameters

                 parameter     s.e. (lin)   r.s.e.(%)   p-value 
ka_pop         :    0.289        0.021           7              
V_pop          :     2.29         0.13           6              
beta_V_tWT0    :    0.181         0.13          74        0.18  
Cl_pop         :    0.314        0.026           8              
beta_Cl_tWT0   :   -0.161         0.22         136        0.46  
beta_Cl_tAGE0  :  -0.0572         0.08         140        0.48  
beta_Cl_SEX_1  :   -0.101        0.079          78         0.2  
beta_Cl_STUD_2 :    0.122        0.072          59        0.09  

omega_ka       :      0.1        0.075          75              
omega_V        :   0.0394         0.11         280              
omega_Cl       :    0.225        0.026          11              

b              :     0.29       0.0097           3              

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correlation matrix of the estimates(linearization)

ka_pop              1                      
V_pop            0.91       1                   
beta_V_tWT0     -0.02   -0.16       1                
Cl_pop           0.02    0.05   -0.03       1             
beta_Cl_tWT0    -0.01   -0.04    0.15    -0.2       1          
beta_Cl_tAGE0   -0.01   -0.01       0   -0.06    0.11       1       
beta_Cl_SEX_1   -0.03   -0.03    0.01   -0.81    0.15    0.08       1    
beta_Cl_STUD_2   0.01    0.01      -0    -0.6   -0.12   -0.01    0.28       1 

Eigenvalues (min, max, max/min): 0.071  2.2  31

omega_ka      1          
omega_V   -0.85       1       
omega_Cl   0.01   -0.01       1    
b         -0.05   -0.08   -0.03       1 

Eigenvalues (min, max, max/min): 0.15  1.8  13

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Estimation of the population parameters by groups

                       parameter     s.e. (lin)   r.s.e.(%) 
Cl_(SEX=0*, STUD=1*) :   0.314         0.026          8     
Cl_(SEX=1 , STUD=1*) :   0.284         0.014          5     
Cl_(SEX=0*, STUD=2 ) :   0.355         0.025          7     
Cl_(SEX=1 , STUD=2 ) :   0.321         0.019          6     

Numerical covariates
	tWT0 = log(WT0)-log(75)  		
	tAGE0 = log(AGE0)-log(45)		

Categorical covariates
	SEX
 		Reference group: 0 
		Other groups:  1
		
	STUD
 		Reference group: 1 
		Other groups:  2
		

Population parameters and Fisher Information Matrix estimation...

Elapsed time is 45.8 seconds. 
CPU time is 16.6 seconds. 
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Log-likelihood Estimation by linearization

-2 x log-likelihood:                   2798.93 
Akaike Information Criteria   (AIC):   2822.93 
Bayesian Information Criteria (BIC):   2845.88 
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